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Anti-Mucin-4/MUC4 Antibody (8K130)

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Catalog No. TMAC-02683

Anti-Mucin-4/MUC4 Antibody (8K130) is a Rabbit antibody targeting Mucin-4/MUC4. Anti-Mucin-4/MUC4 Antibody (8K130) can be used in WB,IHC,FCM.

Anti-Mucin-4/MUC4 Antibody (8K130)

Anti-Mucin-4/MUC4 Antibody (8K130)

😃Good
Catalog No. TMAC-02683
Anti-Mucin-4/MUC4 Antibody (8K130) is a Rabbit antibody targeting Mucin-4/MUC4. Anti-Mucin-4/MUC4 Antibody (8K130) can be used in WB,IHC,FCM.
Pack SizePriceAvailabilityQuantity
50 μL$2977-10 days
100 μL$4967-10 days
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Product Introduction

Bioactivity
Description
Anti-Mucin-4/MUC4 Antibody (8K130) is a Rabbit antibody targeting Mucin-4/MUC4. Anti-Mucin-4/MUC4 Antibody (8K130) can be used in WB,IHC,FCM.
Ig Type
IgG
Reactivity
Human,Rat
Application
Recommended Dose
WB: 1:500; IHC: 1:50-200; FCM: 1:50-100
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundMucins are a group of high molecular weight glycoproteins consisting of a mucin core protein and O-linked carbohydrates. Mucin 4, a membrane-bound mucin, is the human homolog of the rat sialomucin complex (SMC). Mucin 4 protein consists of Mucin 4α, a large amino mucin type subunit, and Mucin 4β, a transmembrane subunit containing three EGF-like domains. The Mucin 4 gene is the predominant mucin gene expressed in the normal urothelium and is also expressed in several normal tissues such as trachea, lung and testis. Dysregulation of Mucin 4 results in high levels of expression in pancreatic tumors and tumor cell lines. Induction of Mucin 4 in pancreatic carcinoma by all-trans-retinoic acid is mediated through the retinoic acid receptor-α signaling pathway. TGFβ2 serves as an interim mediator of this regulated expression. Alternative splicing in the 3'-end of the Mucin 4 gene generates at least 12 splice variants, which are characterized as two distinct types, a secreted type and a membrane-associated type. Mucin 4 protein acts as a heterodimeric bifunctional cell-surface glycoprotein and forms thick mucous effusion in the diseased middle ear.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 120 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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