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Montelukast sodium

Name: Montelukast sodium
Brand: TargetMol
SKU: T1677L
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1677LCas No. 151767-02-1

Alias MK0476

Montelukast sodium (MK0476) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury.

Montelukast sodium

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Purity: 99.89%

Catalog No. T1677LAlias MK0476Cas No. 151767-02-1

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$41	In Stock	In Stock
100 mg	$66	In Stock	In Stock
500 mg	$132	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Color:White

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Product Introduction

Bioactivity

Description	Montelukast sodium (MK0476) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury.
In vitro	Administering 6 mg/kg of Montelukast once daily for 20 days significantly inhibits the increase of eosinophils in both the BAL fluid and lung tissue in mice stimulated by OVA, while also elevating the IL-5 levels in the BAL fluid. OVA stimulation leads to an upsurge in CysLT1 receptor mRNA expression but a decrease in CysLT2 receptor mRNA expression. Following OVA stimulation, Montelukast suppresses the elevated expression of CysLT1 without diminishing the expression of CysLT2.
In vivo	Montelukast acts by binding to the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchi, thereby blocking the effects of leukotriene D4. This action prevents airway edema, smooth muscle contraction, and secretion of viscous liquids, reduces bronchoconstriction caused by leukotrienes, and diminishes inflammation occurrence.
Cell Research	Nasal mucosa and polyp epithelial cells are stimulated with fetal bovine serum (FBS) with or without MK for 24 hours, and cytokine concentrations in epithelial secretions are measured by ELISA. After incubating peripheral blood eosinophils with epithelial cell-conditioned media (ECM) with or without montelukast up to 3 days, eosinophil survival is assessed by Trypan blue dye exclusion[1].
Synonyms	MK0476

Chemical Properties

Molecular Weight	608.17
Formula	C₃₅H₃₅ClNNaO₃S
Cas No.	151767-02-1
Smiles	C(S[C@@H](c1cc(/C=C/c2nc3c(cc2)ccc(c3)Cl)ccc1)CCc1c(cccc1)C(O)(C)C)C1(CC1)CC(=O)[O-].[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

The compound is unstable in solution. Please use soon | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 30.4 mg/mL (49.99 mM), Sonication is recommended. (The compound is unstable in solution, please use soon.)

DMSO: 250 mg/mL (411.07 mM), Sonication is recommended. The compound is unstable in solution, please use soon.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6443 mL	8.2214 mL	16.4428 mL	82.2139 mL
5 mM	0.3289 mL	1.6443 mL	3.2886 mL	16.4428 mL
10 mM	0.1644 mL	0.8221 mL	1.6443 mL	8.2214 mL
20 mM	0.0822 mL	0.4111 mL	0.8221 mL	4.1107 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0329 mL	0.1644 mL	0.3289 mL	1.6443 mL
100 mM	0.0164 mL	0.0822 mL	0.1644 mL	0.8221 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc