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STX-107

🥰Excellent
Catalog No. T202605Cas No. 935685-90-8
Alias STX107, STX 107

STX-107 is a potent and selective mGluR5 agonist for the study of Fragile X Syndrome.

STX-107

STX-107

🥰Excellent
Purity: 99.17%
Catalog No. T202605Alias STX107, STX 107Cas No. 935685-90-8
STX-107 is a potent and selective mGluR5 agonist for the study of Fragile X Syndrome.
Pack SizePriceAvailabilityQuantity
1 mg$390In Stock
5 mg$850In Stock
10 mg$1,280In Stock
25 mg$2,170In Stock
50 mg$3,260In Stock
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Purity:99.17%
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Product Introduction

Bioactivity
Description
STX-107 is a potent and selective mGluR5 agonist for the study of Fragile X Syndrome.
In vitro
Treatment of hippocampal neuron cultures with STX-107 (1 μM for 24 hours) significantly inhibited excessive mGluR5-mediated signaling and restored dendritic spine density and synaptic protein levels in FMR1-deficient mouse neurons, indicating its ability to modulate synaptic plasticity in vitro[1].
In vivo
In Fmr1 knockout mice, intraperitoneal injection of STX-107 (10 mg/kg once daily for 7 days) significantly reduced autism-like hyperactivity and excessive exploratory behavior. The compound also partially restored deficits in social interaction and abnormal startle response, demonstrating its potential to ameliorate behavioral phenotypes in vivo[1].
AliasSTX107, STX 107
Chemical Properties
Molecular Weight319.36
FormulaC18H10FN3S
Cas No.935685-90-8
SmilesN#CC1=CC(F)=CC(=C1)C2=NC=C(C#CC=3N=C(SC3)C)C=C2
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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