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STX-107 is a potent and selective mGluR5 agonist for the study of Fragile X Syndrome.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $390 | In Stock | |
5 mg | $850 | In Stock | |
10 mg | $1,280 | In Stock | |
25 mg | $2,170 | In Stock | |
50 mg | $3,260 | In Stock |
Description | STX-107 is a potent and selective mGluR5 agonist for the study of Fragile X Syndrome. |
In vitro | Treatment of hippocampal neuron cultures with STX-107 (1 μM for 24 hours) significantly inhibited excessive mGluR5-mediated signaling and restored dendritic spine density and synaptic protein levels in FMR1-deficient mouse neurons, indicating its ability to modulate synaptic plasticity in vitro[1]. |
In vivo | In Fmr1 knockout mice, intraperitoneal injection of STX-107 (10 mg/kg once daily for 7 days) significantly reduced autism-like hyperactivity and excessive exploratory behavior. The compound also partially restored deficits in social interaction and abnormal startle response, demonstrating its potential to ameliorate behavioral phenotypes in vivo[1]. |
Alias | STX107, STX 107 |
Molecular Weight | 319.36 |
Formula | C18H10FN3S |
Cas No. | 935685-90-8 |
Smiles | N#CC1=CC(F)=CC(=C1)C2=NC=C(C#CC=3N=C(SC3)C)C=C2 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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