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Anti-CALR Monoclonal Antibody (4U90)
(Synonyms: SSA, RO, HEL-S-99n, CRT, cC1qR) Copy Product Info
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Synonyms: SSA, RO, HEL-S-99n, CRT, cC1qR
Catalog No. TMAT-0203 Copy Product Info
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Anti-CALR Monoclonal Antibody (4U90) is a Mouse antibody targeting CALR. Anti-CALR Monoclonal Antibody (4U90) can be used in WB,IHC,FCM.
Anti-CALR Monoclonal Antibody
(4U90)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 20 µL | Inquiry | 7-10 days | 7-10 days | |
| 50 µL | Inquiry | 7-10 days | 7-10 days | |
| 100 µL | Inquiry | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Stability & Storage
| Description | Anti-CALR Monoclonal Antibody (4U90) is a Mouse antibody targeting CALR. Anti-CALR Monoclonal Antibody (4U90) can be used in WB,IHC,FCM. |
| Synonyms | SSA, RO, HEL-S-99n, CRT, cC1qR |
| Ig Type | IgG1 |
| Clone | 4U90 |
| Reactivity | Human, Mouse, Rat |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/ml |
| Research Background | Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human CALR (AA: 18-417) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | CALR |
| Gene ID | |
| Protein Name | Calreticulin |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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