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Anti-Mer Antibody (1I498)
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Catalog No. TMAC-02563
Alias Tyro12, RP38, MGC133349, MERTK, MER, c-mer, c-Eyk
Anti-Mer Antibody (1I498) is a Rabbit antibody targeting Mer. Anti-Mer Antibody (1I498) can be used in WB,IHC,IP.
Anti-Mer Antibody (1I498)
Anti-Mer Antibody (1I498)
😃Good
Catalog No. TMAC-02563Alias Tyro12, RP38, MGC133349, MERTK, MER, c-mer, c-Eyk
Anti-Mer Antibody (1I498) is a Rabbit antibody targeting Mer. Anti-Mer Antibody (1I498) can be used in WB,IHC,IP.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $297 | 7-10 days | |
| 100 μL | $496 | 7-10 days |
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Chemical Properties
| Description | Anti-Mer Antibody (1I498) is a Rabbit antibody targeting Mer. Anti-Mer Antibody (1I498) can be used in WB,IHC,IP. |
| Synonyms | Tyro12, RP38, MGC133349, MERTK, MER, c-mer, c-Eyk |
| Ig Type | IgG |
| Clone | 1I498 |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of MERTK on 293 cell lysates using anti-MERTK antibody at 1/1,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-MERTK antibody. Counter stained with hematoxylin. |
| Application | |
| Recommended Dose | WB: 1:1000-2000; IHC: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulin-like C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2 (PI-PLC 2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 188 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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