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G0507

Name: G0507
Brand: TargetMol
SKU: T11343
Rating: 4.5 (1 reviews)

(Synonyms: G 0507, 5-(4-methoxyphenyl)-6-(5-methyl-2-thienyl)-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione) Copy Product Info

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Synonyms: G 0507, 5-(4-methoxyphenyl)-6-(5-methyl-2-thienyl)-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione

Catalog No. T11343 Copy Product Info

Purity: 98.98%

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G0507 (5-(4-methoxyphenyl)-6-(5-methyl-2-thienyl)-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione) is a pyrrolopyrimidinedione compound that effectively inhibits the LolCDE ABC transporter. It suppresses the growth of Escherichia coli and induces the extracytoplasmic σE stress response. G0507 is commonly used as a chemical probe to study lipoprotein transport in Gram-negative bacteria.

Cas No. 1223998-29-5

Pack Size	Price	USA Stock	Global Stock
5 mg	$497	6-8 weeks	6-8 weeks
25 mg	$1,270	6-8 weeks	6-8 weeks
50 mg	$1,650	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:98.98%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	G0507 (5-(4-methoxyphenyl)-6-(5-methyl-2-thienyl)-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione) is a pyrrolopyrimidinedione compound that effectively inhibits the LolCDE ABC transporter. It suppresses the growth of Escherichia coli and induces the extracytoplasmic σE stress response. G0507 is commonly used as a chemical probe to study lipoprotein transport in Gram-negative bacteria.
In vitro	Method: E. coli imp4213 strain was treated with G0507 (4× MIC, i.e., 4 μg/ml) for 2 hours. Morphological changes were observed by fluorescence microscopy. Localization of Lpp was analyzed by sucrose density gradient centrifugation combined with Western blot. Processing status of Lpp was assessed by SDS-PAGE and LC-MS. Result: G0507 caused swelling of the periplasmic space at the bacterial poles. Lpp abnormally accumulated in the inner membrane. The accumulated Lpp was fully processed. The MIC values of G0507 against imp4213 and ΔtolC strains were 1 μg/ml and 0.5 μg/ml, respectively, while it showed no activity against wild-type MG1655 (>64 μg/ml)[1].
Synonyms	G 0507, 5-(4-methoxyphenyl)-6-(5-methyl-2-thienyl)-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione

Chemical Properties

Molecular Weight	353.40
Formula	C₁₈H₁₅N₃O₃S
Cas No.	1223998-29-5
Smiles	O=C1NC(=O)C2=C(N1)NC(C=3SC(=CC3)C)=C2C=4C=CC(OC)=CC4
Relative Density.	1.359 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5.00 mg/mL (14.15 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8297 mL	14.1483 mL	28.2965 mL	141.4827 mL
5 mM	0.5659 mL	2.8297 mL	5.6593 mL	28.2965 mL
10 mM	0.2830 mL	1.4148 mL	2.8297 mL	14.1483 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc