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JW 67

Name: JW 67
Brand: TargetMol
SKU: T22884
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22884Cas No. 442644-28-2

JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.

JW 67

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Purity: 99.02%

Catalog No. T22884Cas No. 442644-28-2

JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.

Pack Size	Price	Availability
1 mg	$38	In Stock
2 mg	$54	In Stock
5 mg	$89	In Stock
10 mg	$139	In Stock
25 mg	$287	In Stock
50 mg	$463	In Stock
100 mg	$682	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Purity:99.02%

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COA LCMS

Product Introduction

Bioactivity

Description	JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.
Targets&IC50	Wnt:1.17μM
In vitro	JW 67 inhibits the canonical?Wnt?signaling with an?IC50?of 1.17μM[1]. JW 67 (1 μM) increased concentration of AXIN2 and decreased the active form of β-catenin[1]. JW 67 (10 or 25μM) reduced growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S[1].

Chemical Properties

Molecular Weight	394.38
Formula	C₂₁H₁₈N₂O₆
Cas No.	442644-28-2
Smiles	O=C1Nc2ccccc2C11OCC2(CO1)COC1(OC2)C(=O)Nc2ccccc12
Relative Density.	1.54 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (152.14 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5356 mL	12.6781 mL	25.3563 mL	126.7813 mL
5 mM	0.5071 mL	2.5356 mL	5.0713 mL	25.3563 mL
10 mM	0.2536 mL	1.2678 mL	2.5356 mL	12.6781 mL
20 mM	0.1268 mL	0.6339 mL	1.2678 mL	6.3391 mL
50 mM	0.0507 mL	0.2536 mL	0.5071 mL	2.5356 mL
100 mM	0.0254 mL	0.1268 mL	0.2536 mL	1.2678 mL

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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