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JW 67

🥰Excellent
Catalog No. T22884Cas No. 442644-28-2

JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.

JW 67

JW 67

🥰Excellent
Purity: 99.02%
Catalog No. T22884Cas No. 442644-28-2
JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$38In StockIn Stock
2 mg$54In StockIn Stock
5 mg$89In StockIn Stock
10 mg$139In StockIn Stock
25 mg$287In StockIn Stock
50 mg$463In StockIn Stock
100 mg$682In StockIn Stock
1 mL x 10 mM (in DMSO)$98In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.02%
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Product Introduction

Bioactivity
Description
JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.
Targets&IC50
Wnt:1.17μM
In vitro
JW 67 inhibits the canonical?Wnt?signaling with an?IC50?of 1.17μM[1]. JW 67 (1 μM) increased concentration of AXIN2 and decreased the active form of β-catenin[1]. JW 67 (10 or 25μM) reduced growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S[1].
Chemical Properties
Molecular Weight394.38
FormulaC21H18N2O6
Cas No.442644-28-2
SmilesO=C1Nc2ccccc2C11OCC2(CO1)COC1(OC2)C(=O)Nc2ccccc12
Relative Density.1.54 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (152.14 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Saline: 2.5 mg/mL (6.34 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5356 mL12.6781 mL25.3563 mL126.7813 mL
5 mM0.5071 mL2.5356 mL5.0713 mL25.3563 mL
10 mM0.2536 mL1.2678 mL2.5356 mL12.6781 mL
20 mM0.1268 mL0.6339 mL1.2678 mL6.3391 mL
50 mM0.0507 mL0.2536 mL0.5071 mL2.5356 mL
100 mM0.0254 mL0.1268 mL0.2536 mL1.2678 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

β-cateninβcateninWnt/β-cateninWnt/betacateninWnt/b-cateninWntmultiproteinJW-67JW67JW 67InhibitorinhibitGSK-3bcomplexCK1beta-cateninbetacateninbcateninAXINAPC
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