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JW 67

Name: JW 67
Brand: TargetMol
SKU: T22884
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22884Cas No. 442644-28-2

JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.

JW 67

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Purity: 99.02%

Catalog No. T22884Cas No. 442644-28-2

JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$32	In Stock	In Stock
5 mg	$53	In Stock	In Stock
10 mg	$83	In Stock	In Stock
25 mg	$172	In Stock	In Stock
50 mg	$278	In Stock	In Stock
100 mg	$409	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.02%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.
Targets&IC50	Wnt:1.17μM
In vitro	JW 67 inhibits the canonical?Wnt?signaling with an?IC50?of 1.17μM[1]. JW 67 (1 μM) increased concentration of AXIN2 and decreased the active form of β-catenin[1]. JW 67 (10 or 25μM) reduced growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S[1].

Chemical Properties

Molecular Weight	394.38
Formula	C₂₁H₁₈N₂O₆
Cas No.	442644-28-2
Smiles	O=C1Nc2ccccc2C11OCC2(CO1)COC1(OC2)C(=O)Nc2ccccc12
Relative Density.	1.54 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (152.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 2.5 mg/mL (6.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5356 mL	12.6781 mL	25.3563 mL	126.7813 mL
5 mM	0.5071 mL	2.5356 mL	5.0713 mL	25.3563 mL
10 mM	0.2536 mL	1.2678 mL	2.5356 mL	12.6781 mL
20 mM	0.1268 mL	0.6339 mL	1.2678 mL	6.3391 mL
50 mM	0.0507 mL	0.2536 mL	0.5071 mL	2.5356 mL
100 mM	0.0254 mL	0.1268 mL	0.2536 mL	1.2678 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc