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VU10010

Name: VU10010
Brand: TargetMol
SKU: T23513
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23513Cas No. 633283-39-3

Alias VU 10010

VU10010 (VU 10010) is allosteric potentiator of M4 acetylcholine receptors.

VU10010

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Purity: 99.36%

Catalog No. T23513Alias VU 10010Cas No. 633283-39-3

VU10010 (VU 10010) is allosteric potentiator of M4 acetylcholine receptors.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$77	In Stock	In Stock
25 mg	$158	In Stock	In Stock
50 mg	$250	In Stock	In Stock
100 mg	$368	In Stock	In Stock
200 mg	$517	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.36%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

VU10010 AI Summary

VU10010 exhibits allosteric activation of the rat recombinant muscarinic M4 receptor, enhancing acetylcholine-induced calcium mobilization, increasing acetylcholine EC50 for calcium mobilization induction, and decreasing acetylcholine Ki for displacement of [3H]NMS from the active binding site. Additionally, it stimulates [35S]GTPgammaS binding and modulates postsynaptic currents in hippocampal pyramidal neurons in rat and mouse models. This compound also demonstrates antiviral activity by inhibiting SARS-CoV-2-induced cytotoxicity in Caco-2 and VERO-6 cells with varying inhibition rates, as well as 19.52% inhibition of SARS-CoV-2 3CL-Pro protease activity at 20 µM. Furthermore, VU10010 shows inhibitory activity against human HDAC6, with 16.5% inhibition using a commercial peptide substrate and 2.55% using a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	VU10010 (VU 10010) is allosteric potentiator of M4 acetylcholine receptors.
Synonyms	VU 10010

Chemical Properties

Molecular Weight	345.85
Formula	C₁₇H₁₆ClN₃OS
Cas No.	633283-39-3
Smiles	Cc1cc(C)c2c(N)c(sc2n1)C(=O)NCc1ccc(Cl)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 50 mg/mL (144.57 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8914 mL	14.4571 mL	28.9143 mL	144.5713 mL
5 mM	0.5783 mL	2.8914 mL	5.7829 mL	28.9143 mL
10 mM	0.2891 mL	1.4457 mL	2.8914 mL	14.4571 mL
20 mM	0.1446 mL	0.7229 mL	1.4457 mL	7.2286 mL
50 mM	0.0578 mL	0.2891 mL	0.5783 mL	2.8914 mL
100 mM	0.0289 mL	0.1446 mL	0.2891 mL	1.4457 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc