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FR194738 free base

Name: FR194738 free base
Brand: TargetMol
SKU: T11321
Price: 83 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11321Cas No. 204067-45-8

FR194738 free base inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.

FR194738 free base

😃Good

Purity: 99.13%

Catalog No. T11321Cas No. 204067-45-8

FR194738 free base inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$83	-	In Stock
5 mg	$179	-	In Stock
10 mg	$260	-	In Stock
25 mg	$407	-	In Stock
50 mg	$547	-	In Stock
100 mg	$708	-	In Stock
1 mL x 10 mM (in DMSO)	$197	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.13%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	FR194738 free base inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.
Targets&IC50	SE (HepG2 cell homogenates):9.8 nM
In vitro	FR194738 free base potently inhibits squalene epoxidase in HepG2 cell homogenate and liver microsomes in dogs and rats. FR194738 free base inhibits hamster liver microsomal squalene epoxidase activity in a concentration-dependent manner with an IC50 of 14 nM[2]. In intact HepG2 cells, FR194738 free base inhibits the incorporation of [14C]acetate into free cholesterol and cholesteryl ester in a concentration-dependent manner(IC50s = 4.9 and 8.0 nM). FR194738 free base induces intracellular [14C]squalene accumulation and increases the incorporation of [14C]acetate into squalene[3].
In vivo	FR194738 free base reduces the serum levels of total, non high density lipoprotein and high density lipoprotein cholesterol, and triglyceride. In hamsters, FR194738 free base(32 mg/kg) increases HMG-CoA reductase activity by 1.3-fold[2].

Chemical Properties

Molecular Weight	439.65
Formula	C₂₇H₃₇NO₂S
Cas No.	204067-45-8
Smiles	CCN(C\C=C\C#CC(C)(C)C)Cc1cccc(OCC(C)(C)OCc2ccsc2)c1
Relative Density.	1.051 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (204.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.51 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2745 mL	11.3727 mL	22.7454 mL	113.7268 mL
5 mM	0.4549 mL	2.2745 mL	4.5491 mL	22.7454 mL
10 mM	0.2275 mL	1.1373 mL	2.2745 mL	11.3727 mL
20 mM	0.1137 mL	0.5686 mL	1.1373 mL	5.6863 mL
50 mM	0.0455 mL	0.2275 mL	0.4549 mL	2.2745 mL
100 mM	0.0227 mL	0.1137 mL	0.2275 mL	1.1373 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc