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Fmoc-Ala-Glu-Asn-Lys-NH2

Name: Fmoc-Ala-Glu-Asn-Lys-NH2
Brand: TargetMol
SKU: T38116
Rating: 4.5 (1 reviews)

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Catalog No. T38116Cas No. 220701-06-4

Alias Fmoc-Ala-Glu-Asn-Lys-NH2

Fmoc-Ala-Glu-Asn-Lys-NH2 is a peptide inhibitor that selectively targets asparagine endopeptidase (AEP) and inhibits the cleavage of amyloid precursor protein (APP). AEP, a pH-controlled cysteine proteinase, plays a crucial role in the proteolytic processing of APP, and its activity is enhanced during the aging process [1].

Fmoc-Ala-Glu-Asn-Lys-NH2

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Catalog No. T38116Alias Fmoc-Ala-Glu-Asn-Lys-NH2Cas No. 220701-06-4

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Product Introduction

Bioactivity

Description	Fmoc-Ala-Glu-Asn-Lys-NH2 is a peptide inhibitor that selectively targets asparagine endopeptidase (AEP) and inhibits the cleavage of amyloid precursor protein (APP). AEP, a pH-controlled cysteine proteinase, plays a crucial role in the proteolytic processing of APP, and its activity is enhanced during the aging process [1].
In vitro	Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, unlike other small molecule inhibitors and the inactive peptide AEQK, which showed no effect [1].
Synonyms	Fmoc-Ala-Glu-Asn-Lys-NH2

Chemical Properties

Molecular Weight	681.747
Formula	C₃₃H₄₃N₇O₉
Cas No.	220701-06-4
Smiles	C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(N)=O
Sequence	Fmoc-Ala-Glu-Asn-Lys-NH2
Sequence Short	AENK

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (146.68 mM), Sonication and heating to 80℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4668 mL	7.3341 mL	14.6682 mL	73.3410 mL
5 mM	0.2934 mL	1.4668 mL	2.9336 mL	14.6682 mL
10 mM	0.1467 mL	0.7334 mL	1.4668 mL	7.3341 mL
20 mM	0.0733 mL	0.3667 mL	0.7334 mL	3.6670 mL
50 mM	0.0293 mL	0.1467 mL	0.2934 mL	1.4668 mL
100 mM	0.0147 mL	0.0733 mL	0.1467 mL	0.7334 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc