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(S)-Timolol Maleate

Name: (S)-Timolol Maleate
Brand: TargetMol
SKU: T0475
Rating: 4.5 (1 reviews)

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Catalog No. T0475Cas No. 26921-17-5

Alias Timolol Maleate, MK 950, L-714,465 (Maleate)

Timolol is a nonselective beta-adrenergic receptor blocker that is widely used for the therapy of hypertension, angina pectoris and prevention of vascular headaches.

(S)-Timolol Maleate

😃Good

Catalog No. T0475Alias Timolol Maleate, MK 950, L-714,465 (Maleate)Cas No. 26921-17-5

Timolol is a nonselective beta-adrenergic receptor blocker that is widely used for the therapy of hypertension, angina pectoris and prevention of vascular headaches.

Pack Size	Price	Availability
25 mg	$30	Backorder
50 mg	$41	Backorder
100 mg	$48	Backorder
200 mg	$82	Backorder
1 mL x 10 mM (in DMSO)	$47	Backorder

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:>99.99%

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COA

Product Introduction

Bioactivity

Description	Timolol is a nonselective beta-adrenergic receptor blocker that is widely used for the therapy of hypertension, angina pectoris and prevention of vascular headaches.
Targets&IC50	β1-adrenoceptor:1.97 nM(Ki), β2-adrenoceptor:2.0 nM(Ki)
In vivo	Timolol Maleate competes with adrenergic neurotransmitters for binding to β1-adrenergic receptors in cardiac and vascular smooth muscle as well as β2- receptors in bronchial and vascular smooth muscle.Timolol Maleate has a higher affinity for β2-adrenergic receptors than for β1-adrenergic receptors.Timolol Maleate has a relatively high lipid solubility, but does not have a significant effect on β2-adrenergic receptors. , but does not have significant intrinsic sympathomimetic or local anesthetic activity.
Synonyms	Timolol Maleate, MK 950, L-714,465 (Maleate)

Chemical Properties

Molecular Weight	432.5
Formula	C₁₇H₂₈N₄O₇S
Cas No.	26921-17-5
Smiles	OC(=O)\C=C/C(O)=O.CC(C)(C)NC[C@H](O)COc1nsnc1N1CCOCC1
Relative Density.	no data available

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (184.97 mM), Sonication is recommended.

Ethanol: 4 mg/mL (9.25 mM), Sonication is recommended.

H2O: <1 mg/mL

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3121 mL	11.5607 mL	23.1214 mL	115.6069 mL
5 mM	0.4624 mL	2.3121 mL	4.6243 mL	23.1214 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2312 mL	1.1561 mL	2.3121 mL	11.5607 mL
20 mM	0.1156 mL	0.5780 mL	1.1561 mL	5.7803 mL
50 mM	0.0462 mL	0.2312 mL	0.4624 mL	2.3121 mL
100 mM	0.0231 mL	0.1156 mL	0.2312 mL	1.1561 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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