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(S)-Timolol Maleate

Name: (S)-Timolol Maleate
Brand: TargetMol
SKU: T0475
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0475Cas No. 26921-17-5

Alias Timolol Maleate, MK 950, L-714,465 (Maleate)

Timolol is a nonselective beta-adrenergic receptor blocker that is widely used for the therapy of hypertension, angina pectoris and prevention of vascular headaches.

(S)-Timolol Maleate

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Catalog No. T0475Alias Timolol Maleate, MK 950, L-714,465 (Maleate)Cas No. 26921-17-5

Timolol is a nonselective beta-adrenergic receptor blocker that is widely used for the therapy of hypertension, angina pectoris and prevention of vascular headaches.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	-	In Stock
50 mg	$41	-	In Stock
100 mg	$48	-	In Stock
200 mg	$82	-	In Stock
1 mL x 10 mM (in DMSO)	$47	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:>99.99%

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Timolol is a nonselective beta-adrenergic receptor blocker that is widely used for the therapy of hypertension, angina pectoris and prevention of vascular headaches.
Targets&IC50	β2-adrenoceptor:2.0 nM(Ki), β1-adrenoceptor:1.97 nM(Ki)
In vivo	Timolol Maleate competes with adrenergic neurotransmitters for binding to β1-adrenergic receptors in cardiac and vascular smooth muscle as well as β2- receptors in bronchial and vascular smooth muscle.Timolol Maleate has a higher affinity for β2-adrenergic receptors than for β1-adrenergic receptors.Timolol Maleate has a relatively high lipid solubility, but does not have a significant effect on β2-adrenergic receptors. , but does not have significant intrinsic sympathomimetic or local anesthetic activity.
Synonyms	Timolol Maleate, MK 950, L-714,465 (Maleate)

Chemical Properties

Molecular Weight	432.5
Formula	C₁₇H₂₈N₄O₇S
Cas No.	26921-17-5
Smiles	OC(=O)\C=C/C(O)=O.CC(C)(C)NC[C@H](O)COc1nsnc1N1CCOCC1
Relative Density.	no data available

Storage & Solubility Information

Storage

store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (184.97 mM), Sonication is recommended.

Ethanol: 4 mg/mL (9.25 mM), Sonication is recommended.

H2O: <1 mg/mL

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3121 mL	11.5607 mL	23.1214 mL	115.6069 mL
5 mM	0.4624 mL	2.3121 mL	4.6243 mL	23.1214 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2312 mL	1.1561 mL	2.3121 mL	11.5607 mL
20 mM	0.1156 mL	0.5780 mL	1.1561 mL	5.7803 mL
50 mM	0.0462 mL	0.2312 mL	0.4624 mL	2.3121 mL
100 mM	0.0231 mL	0.1156 mL	0.2312 mL	1.1561 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc