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Diltiazem

Name: Diltiazem
Brand: TargetMol
SKU: T0112L
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0112LCas No. 42399-41-7

Alias Dilzen, CRD401 free base

Diltiazem (CRD 401 free base) is an orally available L-type Ca2+ channel blocker with antihypertensive, antiarrhythmic, and cardioprotective properties that prevent post-reperfusion myocardial injury, angina pectoris, and cardiovascular-related diseases.

Diltiazem

🥰Excellent

Purity: 99.83%

Catalog No. T0112LAlias Dilzen, CRD401 free baseCas No. 42399-41-7

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	-	In Stock
100 mg	$40	-	In Stock
500 mg	$98	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.83%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Diltiazem (CRD 401 free base) is an orally available L-type Ca2+ channel blocker with antihypertensive, antiarrhythmic, and cardioprotective properties that prevent post-reperfusion myocardial injury, angina pectoris, and cardiovascular-related diseases.
In vivo	In male ApoE−/− mice with angiotensin II-induced aneurysms, Diltiazem free base (100 mg/kg, oral administration, in drinking water, for 4 weeks) significantly reduced vascular remodeling but also lowered blood pressure[3].
Synonyms	Dilzen, CRD401 free base

Chemical Properties

Molecular Weight	414.52
Formula	C₂₂H₂₆N₂O₄S
Cas No.	42399-41-7
Smiles	O(C(C)=O)[C@@H]1[C@@H](SC=2C(N(CCN(C)C)C1=O)=CC=CC2)C3=CC=C(OC)C=C3
Relative Density.	1.26 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 252.5 mg/mL (609.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.96 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4124 mL	12.0621 mL	24.1243 mL	120.6214 mL
5 mM	0.4825 mL	2.4124 mL	4.8249 mL	24.1243 mL
10 mM	0.2412 mL	1.2062 mL	2.4124 mL	12.0621 mL
20 mM	0.1206 mL	0.6031 mL	1.2062 mL	6.0311 mL
50 mM	0.0482 mL	0.2412 mL	0.4825 mL	2.4124 mL
100 mM	0.0241 mL	0.1206 mL	0.2412 mL	1.2062 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc