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Glutathione peroxidase (GPx) is an important peroxide disintegrating enzyme widely present in the organism.The active center of GSx is selenocysteine, and the amount of its activity can reflect the selenium level of the organism. Selenium is a component of the GSx enzyme system, which catalyzes the change of GSH to GSSG and the reduction of toxic peroxides to non-toxic hydroxyl compounds, thus protecting the structure and function of cell membranes from the interference and damage caused by peroxides.The reduction of NADPH is linearly correlated with the activity of glutathione peroxidase.

  • JKE-1674
    JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.
    • $48
    In Stock
    TargetMol | Inhibitor Hot
  • RSL3
    RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of ferroptosis that is selective for tumor cells carrying oncogenic RAS.
    • $33
    In Stock
    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • ML162
    ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively)
    • $91
    In Stock
    TargetMol | Citations Cited
  • ML-210
    ML-210 (CID 49766530) is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity
    • $34
    In Stock
    TargetMol | Citations Cited
  • GPX4-IN-5
    GPX4-IN-5 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-5 induces ferroptosis and can be used for the prevention and treatment of triple-negative breast cancer (TNBC).
    • $63
    In Stock
    TargetMol | Inhibitor Sale
  • GPX4-IN-6
    GPX4-IN-6 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-6 induces ferroptosis and is used for the treatment= and prevention of triple negative breast cancer (TNBC).
    • $64
    In Stock
    TargetMol | Inhibitor Sale
  • N6F11
    N6F11 is a novel, selective and potent inducer of ferroptosis with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cancer cells.N6F11 can be used to study pancreatic cancer.
    • $195
    In Stock
  • PKUMDL-LC-101-D04
    PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of ferroptosis. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 μM in a cell-free assay, and at a concentration of 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts.PKUMDL-LC-101-D04 (200 μM) reduced cholesterol peroxide-induced MEF death.
    • $80
    In Stock
  • 3-Deoxyglucosone
    3-Deoxyglucosone(3-Deoxy-D-glucosone) is synthesized by the intermediate pathway of the melad and polyol reactions.3-Deoxyglucosone reacts rapidly with protein amino groups to form advanced glycosylated end proteins (AGEs).3-Deoxyglucosone inactivates glutathione peroxidase and synergizes with low glucose to enhance GLP-1 secretion.3-Deoxyglucosone is used as a biomarker for diabetes mellitus.3-Deoxyglucosone has been shown to be an inhibitor of GLP-1 secretion in the presence of low glucose. 3-Deoxyglucosone inactivates glutathione oxidase, synergizes with low glucose to enhance GLP-1 secretion, and can be used as a biologic marker for diabetes.
    • $188
    In Stock
  • Misonidazole
    Misonidazole as a novel GPX inhibitors to cause oxidative stress in chemotherapy-resistant tumors.
    • $42
    In Stock
    TargetMol | Inhibitor Sale
  • BCP-T.A
    BCP-T.A is an ferroptosis inducer that acts by binding to GPX4.
    • $78
    In Stock