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Heptamidine dimethanesulfonate

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Catalog No. T11553Cas No. 161374-55-6
Alias SBi4211 dimethanesulfonate

Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) serves as a potent inhibitor related to Pentamidine, targeting the calcium-binding protein S100B with a dissociation constant (Kd) of 6.9 µM. It demonstrates specificity by preferentially killing melanoma cells overexpressing S100B compared to cells lacking this protein. Additionally, Heptamidine is employed as a valuable research tool in the study of Myotonic dystrophy (DM).

Heptamidine dimethanesulfonate
Other Forms of Heptamidine dimethanesulfonate:
HeptamidineT11553L94345-47-8
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Heptamidine dimethanesulfonate

🥰Excellent
Purity: 97.8%
Catalog No. T11553Alias SBi4211 dimethanesulfonateCas No. 161374-55-6
Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) serves as a potent inhibitor related to Pentamidine, targeting the calcium-binding protein S100B with a dissociation constant (Kd) of 6.9 µM. It demonstrates specificity by preferentially killing melanoma cells overexpressing S100B compared to cells lacking this protein. Additionally, Heptamidine is employed as a valuable research tool in the study of Myotonic dystrophy (DM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$39In StockIn Stock
5 mg$89In StockIn Stock
10 mg$135In StockIn Stock
25 mg$228In StockIn Stock
50 mg$347In StockIn Stock
100 mg$496In StockIn Stock
200 mg$693In StockIn Stock
1 mL x 10 mM (in DMSO)$109In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:97.8%
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Product Introduction

Bioactivity
Description
Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) serves as a potent inhibitor related to Pentamidine, targeting the calcium-binding protein S100B with a dissociation constant (Kd) of 6.9 µM. It demonstrates specificity by preferentially killing melanoma cells overexpressing S100B compared to cells lacking this protein. Additionally, Heptamidine is employed as a valuable research tool in the study of Myotonic dystrophy (DM).
Targets&IC50
S100B:(kd)6.9 μM
In vitro
Heptamidine rescues the mis-splicing of minigene reporters in a HeLa cell DM1 model (EC50: 15 μM). Heptamidine (20 μM) does not decrease CUG levels significantly when compares to Propamidine and Pentamidine, and exhibits cytotoxic at concentrations above 17.5 μM in HeLa cells expressing 960 CUG repeats [2].
In vivo
Heptamidine (i.p.; 20 or 30 mg/kg; 7 days) causes a dose-dependent reduction of exon 7a inclusion in HSALR mice, returning to wild type levels (6±1%) when at 20 mg/kg dose, the myotonia is reduced from grade 3 to grade 1 (occasional myotonic discharge) or grade 0 at both 20 or 30 mg/kg [2].
SynonymsSBi4211 dimethanesulfonate
Chemical Properties
Molecular Weight560.68
FormulaC23H36N4O8S2
Cas No.161374-55-6
SmilesCS(O)(=O)=O.CS(O)(=O)=O.NC(=N)c1ccc(OCCCCCCCOc2ccc(cc2)C(N)=N)cc1
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 8.33 mg/mL (14.86 mM), Sonication is recommended.
DMSO: 70 mg/mL (124.85 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.57 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.7835 mL8.9177 mL17.8355 mL89.1774 mL
5 mM0.3567 mL1.7835 mL3.5671 mL17.8355 mL
10 mM0.1784 mL0.8918 mL1.7835 mL8.9177 mL
DMSO
1mg5mg10mg50mg
20 mM0.0892 mL0.4459 mL0.8918 mL4.4589 mL
50 mM0.0357 mL0.1784 mL0.3567 mL1.7835 mL
100 mM0.0178 mL0.0892 mL0.1784 mL0.8918 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SBi-4211SBi4211SBi 4211S100BMyotonicmelanomaInhibitorinhibitHeptamidine dimethanesulfonateHeptamidineHeLadystrophycellcancercalcium-binding protein S100BCalcium-Binding
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