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Anti-A4GALT Polyclonal Antibody
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Catalog No. TMAB-02122
Anti-A4GALT Polyclonal Antibody is a Rabbit antibody targeting A4GALT. Anti-A4GALT Polyclonal Antibody can be used in WB.
Anti-A4GALT Polyclonal Antibody
Anti-A4GALT Polyclonal Antibody
😃Good
Catalog No. TMAB-02122
Anti-A4GALT Polyclonal Antibody is a Rabbit antibody targeting A4GALT. Anti-A4GALT Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-A4GALT Polyclonal Antibody is a Rabbit antibody targeting A4GALT. Anti-A4GALT Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat,Dog,Cow,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Golgi apparatus membrane; Single-pass type II membrane protein (Probable). |
| Tissue Specificity | Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.Expression of CD77, also called Gb3, sensitizes a cell to verotoxins, causing cellular injury that can lead to disease. Therefore, the complex regulation of CD77 biosynthesis and the activity of the enzymes involved, such as CD77 synthase, can be studied by compared gene expression between toxin-sensitive and insensitive tissues and cell lines. The highest tissue expression of CD77 synthase occurs in the kidney, mesenteric lymph node, spleen, and brain. Burkitt leukemia cells express very high levels of CD77 as well as CD77 synthase, and are sensitive to verotoxin induced apoptosis. These megakaryoblasts then never mature, leading to the arrest of platelet generation in the bone marrow, which may cause thrombocytopenia, a symptom associated with various hemorrhagic conditions. |
| Immunogen | KLH conjugated synthetic peptide: human A4GALT |
| Antigen Species | Human |
| Gene Name | A4GALT |
| Gene ID | |
| Protein Name | Lactosylceramide 4-alpha-galactosyltransferase |
| Uniprot ID | |
| Function | Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins. |
| Molecular Weight | Theoretical: 40 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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