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AMG 837 calcium hydrate

Name: AMG 837 calcium hydrate
Brand: TargetMol
SKU: TQ0020
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0020Cas No. 1259389-38-2

AMG 837 calcium hydrate, a potent GPR40 agonist with an EC50 of 13 nM, exhibits high selectivity over GPR41, GPR43, and GPR120 (EC50 > 10,000 nM).

AMG 837 calcium hydrate

🥰Excellent

Purity: 98.07%

Catalog No. TQ0020Cas No. 1259389-38-2

AMG 837 calcium hydrate, a potent GPR40 agonist with an EC50 of 13 nM, exhibits high selectivity over GPR41, GPR43, and GPR120 (EC50 > 10,000 nM).

Pack Size	Price	Availability
2 mg	$31	In Stock
5 mg	$48	In Stock
10 mg	$73	In Stock
25 mg	$153	In Stock
50 mg	$259	In Stock
100 mg	$416	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock

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Purity:98.07%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	AMG 837 calcium hydrate, a potent GPR40 agonist with an EC50 of 13 nM, exhibits high selectivity over GPR41, GPR43, and GPR120 (EC50 > 10,000 nM).
Targets&IC50	FFA1/GPR40:13 nM (EC50)
In vitro	GPR40 agonist AMG 837 displayed the expected two-fold increase in potency on GPR4 (EC50: 13 nM) compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40 (EC50s: 23/13 nM). AMG 837 was a partial agonist on GPR40 with maximal activity 85% of that shown by DHA. An external panel of 64 receptors also revealed no significant activity with the exception of weak inhibition (IC50: 3 μM) on the α2-adrenergic receptor [1].
In vivo	In rats, AMG 837 increases insulin release when glucose levels are elevated [2].

Chemical Properties

Molecular Weight	950.97
Formula	C₅₂H₄₄CaF₆O₈
Cas No.	1259389-38-2
Smiles	[H]O[H].[H]O[H].O=C([O-])C[C@H](C#CC)C1=CC=C(OCC2=CC(C3=CC=C(C(F)(F)F)C=C3)=CC=C2)C=C1.O=C([O-])C[C@H](C#CC)C4=CC=C(OCC5=CC(C6=CC=C(C(F)(F)F)C=C6)=CC=C5)C=C4.[Ca+2]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (42.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0516 mL	5.2578 mL	10.5156 mL	52.5779 mL
5 mM	0.2103 mL	1.0516 mL	2.1031 mL	10.5156 mL
10 mM	0.1052 mL	0.5258 mL	1.0516 mL	5.2578 mL
20 mM	0.0526 mL	0.2629 mL	0.5258 mL	2.6289 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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