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[D-Trp34]-Neuropeptide Y Acetate

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Catalog No. TP1984L
Alias [D-Trp34]-Neuropeptide Y Acetate (153549-84-9 Free base)

[D-Trp34]-Neuropeptide Y Acetate is a potent and selective agonist of neuropeptide Y (NPY) Y5 receptor. [D-Trp34]-Neuropeptide acetate Y is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-Trp34]-Neuropeptide Y Acetate markedly increases food intake in rats.

[D-Trp34]-Neuropeptide Y Acetate
Other Forms of [D-Trp34]-Neuropeptide Y Acetate:
[D-Trp34]-Neuropeptide YTP1984153549-84-9
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[D-Trp34]-Neuropeptide Y Acetate

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Purity: 99.73%
Catalog No. TP1984LAlias [D-Trp34]-Neuropeptide Y Acetate (153549-84-9 Free base)
[D-Trp34]-Neuropeptide Y Acetate is a potent and selective agonist of neuropeptide Y (NPY) Y5 receptor. [D-Trp34]-Neuropeptide acetate Y is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-Trp34]-Neuropeptide Y Acetate markedly increases food intake in rats.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$117-In Stock
5 mg$270-In Stock
10 mg$405-In Stock
25 mg$692-In Stock
50 mg$1,030-In Stock
100 mg$1,550-In Stock
200 mg$2,080-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.73%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
[D-Trp34]-Neuropeptide Y Acetate is a potent and selective agonist of neuropeptide Y (NPY) Y5 receptor. [D-Trp34]-Neuropeptide acetate Y is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-Trp34]-Neuropeptide Y Acetate markedly increases food intake in rats.
In vitro
[D-Trp34]-Neuropeptide Y Acetate exhibits pKi values of 6.49, 5.43, 7.08, 7.53, 6.55, 5.95, 6.85, 7.41 for hY1, hY2, hY4, hY5, rY1, rY2, rY4, rY5 in CHO cells. [D-Trp34]-Neuropeptide Y Acetate exhibits pEC50 values of 6.44, <6, 6.28，7.82 for rY1, rY2 in CHO cells and rY4, rY5 in HEK-293 cells[1].
In vivo
[D-Trp34]-Neuropeptide Y Acetate (0, 8 and 16 μg/rat; I.C.V) stimulats food intake to the same extent in both lean and obese rats 1 h after injection at a dose of 16 μg in male Zucker rats[2].
Synonyms[D-Trp34]-Neuropeptide Y Acetate (153549-84-9 Free base)
Chemical Properties
Molecular Weight4371.78
FormulaC198H293N55O58
SmilesCC[C@@H]([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H]2CCCN2C([C@@H](NC([C@@H](NC([C@@H]3CCCN3C([C@@H](NC([C@@H](NC([C@@H]4CCCN4C([C@@H](N)CC5=CC=C(O)C=C5)=O)=O)CO)=O)CCCCN)=O)=O)CC(O)=O)=O)CC(N)=O)=O)=O)=O)CCC(O)=O)=O)CC(O)=O)=O)C)=O)=O)C)=O)CCC(O)=O)=O)CC(O)=O)=O)CC(C)C)=O)C)=O)CCCNC(N)=N)=O)CC6=CC=C(O)C=C6)=O)CC7=CC=C(O)C=C7)=O)CO)=O)C)=O)CC(C)C)=O)CCCNC(N)=N)=O)CC8=CNC=N8)=O)CC9=CC=C(O)C=C9)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N)=O)CC%10=CC=C(O)C=C%10)=O)CCCNC(N)=N)=O)CC%11=CNC%12=CC=CC=C%12%11)=O)CCCNC(N)=N)=O)[C@H](O)C)=O)[C@H](CC)C)=O)CC(C)C)=O)CC(N)=O)=O)C.CC(O)=O
Relative Density.no data available
SequenceH-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-D-Trp-Arg-Tyr-NH2
Sequence ShortYPSKPDNPGEDAPAEDLARYYSALRHYINLITR-{D-Trp}-RY
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

NeuropeptideYReceptorNeuropeptide Y Receptorneuropeptide Y (NPY) Y5 receptor153549-84-9 Free base153549-84-9[D-Trp34]-Neuropeptide Y Acetate
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