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Steppogenin
(Synonyms: Norartocarpanone) Copy Product Info
🥰Excellent
Synonyms: Norartocarpanone
Catalog No. TN5448 Copy Product Info
Purity: 99.98%
🥰Excellent
Steppogenin exhibits significant tyrosinase inhibition activity, with IC50 values below 50 μM in mushroom tyrosinase assays and greater potency than kojic acid (IC50 = 71.6 μM). Steppogenin is utilized in biochemical research focused on melanogenesis regulation, tyrosinase enzymatic inhibition mechanisms, and pigment biosynthesis pathway studies.
Cas No. 56486-94-3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $219 | - | In Stock | |
| 5 mg | $550 | - | In Stock | |
| 10 mg | $792 | - | In Stock | |
| 25 mg | $1,220 | - | In Stock | |
| 50 mg | $1,630 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.98%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Steppogenin exhibits significant tyrosinase inhibition activity, with IC50 values below 50 μM in mushroom tyrosinase assays and greater potency than kojic acid (IC50 = 71.6 μM). Steppogenin is utilized in biochemical research focused on melanogenesis regulation, tyrosinase enzymatic inhibition mechanisms, and pigment biosynthesis pathway studies. |
| Targets & IC50 | HIF1α:0.56 ± 0.043 μM, DLL4:8.46 ± 1.08 μM |
| In vitro | Methods:HEK293T cells and vascular endothelial cells were treated with Steppogenin at different concentrations for various durations, and a hypoxia model was established. The transcriptional activity of HIF-1α, expression of related genes and proteins, as well as proliferation, migration and spheroid sprouting ability of endothelial cells were detected. Results: 1.After 24-hour treatment with 0–10 μM Steppogenin, the HIF-1α transcriptional activity in hypoxic HEK293T cells was suppressed in a concentration-dependent manner. Meanwhile, VEGF-induced DLL4 expression was downregulated in vascular endothelial cells. 2.Under hypoxic conditions, 6-hour treatment with 0–3 μM Steppogenin markedly reduced the mRNA levels of HIF-1α downstream target genes, including VEGF, GLUT1, CXCR4 and CA9. 3.Treatment with 0–3 μM Steppogenin for 16 hours decreased HIF-1α protein content and downregulated the protein expression of VEGF, CXCR4 and CA9. 4.After 24-hour incubation with 0–3 μM Steppogenin, hypoxia-induced proliferation and migration of vascular endothelial cells, as well as VEGF-mediated endothelial spheroid sprouting were inhibited [1]. |
| In vivo | Methods:Tumor-bearing mice received a single intraperitoneal injection of 2 mg/kg Steppogenin. Tumor growth and angiogenesis were observed. Tissue distribution, area under the curve (AUC) and half-life (T₁/₂) of the drug were also determined. Results:This administration regimen effectively inhibited tumor growth and angiogenesis. Steppogenin accumulated most abundantly in the liver and spleen, with AUC ratios of 25.5-fold and 9.74-fold respectively. Its half-life was significantly prolonged in these two tissues [1]. |
| Synonyms | Norartocarpanone |
| Molecular Weight | 288.25 |
| Formula | C15H12O6 |
| Cas No. | 56486-94-3 |
| Smiles | O=C1C=2C(O[C@@H](C1)C3=C(O)C=C(O)C=C3)=CC(O)=CC2O |
| Relative Density. | no data available |
| Storage | Keep away from direct sunlight, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 2.4 mg/mL (8.33 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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Related Tags: Steppogenin chemical structure | Steppogenin in vivo | Steppogenin in vitro | Steppogenin formula | Steppogenin molecular weight
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