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LY 344864 hydrochloride
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Catalog No. T41295Cas No. 1217756-94-9
LY 344864 hydrochloride is a selective receptor agonist with an affinity of 6 nM (Ki) at the 5-HT1F receptor.
LY 344864 hydrochloride
Copy Product Info😃Good
Catalog No. T41295Cas No. 1217756-94-9
LY 344864 hydrochloride is a selective receptor agonist with an affinity of 6 nM (Ki) at the 5-HT1F receptor.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $287 | 35 days | 35 days | |
| 10 mg | $548 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Chemical Properties
Storage & Solubility Information
| Description | LY 344864 hydrochloride is a selective receptor agonist with an affinity of 6 nM (Ki) at the 5-HT1F receptor. |
| Targets&IC50 | 5-HT2B receptor (human):1.695 μM (Ki), 5-HT2C receptor (human):3.499 μM (Ki), 5-HT1D receptor (human):0.575 μM (Ki), α1 adrenoceptor (rat):5.06 μM (Ki), α2 adrenergic receptor (rat):3.69 μM (Ki), 5-HT3A Receptor (human):3.935 μM (Ki), 5-HT1B receptor (human):0.549 μM (Ki), 5-HT7 receptor (human):4.851 μM (Ki), 5-HT1A receptor (human):0.530 μM (Ki), 5-HT1F receptor (human):0.006 μM (Ki), 5-HT1E receptor (human):1.415 μM (Ki) |
| In vitro | LY344864 is a selective 5-HT1F receptor agonist with an affinity of 6 nM (Ki). It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolininduced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 is shown to be a full agonist producing an effect similar in magnitude to serotonin itself [1]. |
| In vivo | After an intravenous dose of 1 mg/kg, rat plasma LY344864 levels decrease over time, whereas brain cortex levels remaine relatively constant for the first 6 hours after injection. Oral and intravenous LY344864 administration potently inhibit dural protein extravasation caused by electrical stimulation of the trigeminal ganglion in rats [1]. Co-injection of LY 344864 and systemically ineffective doses of METH significantly decreases preference scores and the rewarding properties of METH during the reinstatement phase. In addition, administration of LY 344864 has no effect on the acquisition of CPP in rats [2]. |
| Molecular Weight | 387.88 |
| Formula | C21H23ClFN3O |
| Cas No. | 1217756-94-9 |
| Smiles | N(C)(C)[C@H]1CC=2C=3C(NC2CC1)=CC=C(NC(=O)C4=CC=C(F)C=C4)C3.Cl |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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