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Dimesna

Name: Dimesna
Brand: TargetMol
SKU: T1672
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1672Cas No. 16208-51-8

Alias BNP-7787

Dimesna (BNP-7787) is a synthetic derivative of dithio-ethane sulfonate with uroprotective properties.

Dimesna

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Purity: 99.90%

Catalog No. T1672Alias BNP-7787Cas No. 16208-51-8

Dimesna (BNP-7787) is a synthetic derivative of dithio-ethane sulfonate with uroprotective properties.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$34	In Stock	In Stock
500 mg	$107	In Stock	In Stock
1 g	$157	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.90%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Dimesna AI Summary

Dimesna exhibits bioactivity as an inhibitor of Plasmodium falciparum proliferation with varying potencies against different strains: 0.9 nM against the 3D7 strain, 298.3 nM against the DD2 strain, 14950.2 nM against the DD2 strain in repeat assays, and 1.7 nM against the HB3 strain. Additionally, Dimesna displays potential antiviral activity against SARS-CoV-2. It inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 0.13% at a concentration of 10 µM after 48 hours and shows 14.1% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM. Another assay indicated minimal inhibition (-0.1%) of SARS-CoV-2 cytotoxicity in Vero-6 cells at 10 µM after 48 hours. This suggests limited but observable antiviral properties, particularly targeting the protease activity of SARS-CoV-2..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dimesna (BNP-7787) is a synthetic derivative of dithio-ethane sulfonate with uroprotective properties.
In vitro	Dimesna modulated paclitaxel-induced MTP hyperpolymerization, and mesna, an in vivo metabolite of Dimesna, prevented cisplatin-induced MTP inactivation. The renal organic anion transporter proteins OAT1 (KM=636 μM), OAT3 (KM=390 μM) and OAT4 (KM=590 μM) were able to specifically bind Dimesna.
In vivo	Dimesna modulated paclitaxel-induced MTP hyperpolymerization, and mesna, an in vivo metabolite of Dimesna, prevented cisplatin-induced MTP inactivation. The renal organic anion transporter proteins OAT1 (KM=636 μM), OAT3 (KM=390 μM) and OAT4 (KM=590 μM) were able to specifically bind Dimesna.
Synonyms	BNP-7787

Chemical Properties

Molecular Weight	326.34
Formula	C₄H₈Na₂O₆S₄
Cas No.	16208-51-8
Smiles	[O-]S(=O)(=O)CCSSCCS(=O)(=O)[O-].[Na+].[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 13 mg/mL (39.84 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0643 mL	15.3214 mL	30.6429 mL	153.2144 mL
5 mM	0.6129 mL	3.0643 mL	6.1286 mL	30.6429 mL
10 mM	0.3064 mL	1.5321 mL	3.0643 mL	15.3214 mL
20 mM	0.1532 mL	0.7661 mL	1.5321 mL	7.6607 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc