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GLP-1 receptor agonist 7

Name: GLP-1 receptor agonist 7
Brand: TargetMol
SKU: T64195
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T64195 Copy Product Info

Purity: 98.17%

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GLP-1 receptor agonist 7 (Compound 130b) is a potent agonist of the Glucagon-like peptide-1 (GLP-1) receptor. It exhibits high affinity for GLP-1R, effectively triggering the generation of intracellular cAMP via G-protein-mediated signaling with an EC50 of ≤ 0.2 nM. As a potent incretin mimetic, this compound modulates glucose homeostasis by enhancing insulin secretion in a glucose-dependent manner. It serves as a significant molecular tool for studying the therapeutic interventions for type 2 diabetes, obesity, and other GLP-1R-related metabolic disorders

GLP-1 receptor agonist 7

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Catalog No. T64195

Cas No. 2736447-04-2

Pack Size	Price	USA Stock	Global Stock	Quantity
2 mg	$59	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:98.17%

Appearance:Solid

Color:White

Resource Download

COA MS HNMR HPLC

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	593.05
Formula	C₃₁H₃₀ClFN₄O₅
Cas No.	2736447-04-2
Smiles	C(N1C=2C(N=C1CN3CCC(CC3)C4=C5C(OC[C@@H](O5)C6=C(F)C=C(Cl)C=C6)=CC=C4)=CC=C(C(O)=O)N2)[C@@H]7CCO7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (168.62 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6862 mL	8.4310 mL	16.8620 mL	84.3099 mL
5 mM	0.3372 mL	1.6862 mL	3.3724 mL	16.8620 mL
10 mM	0.1686 mL	0.8431 mL	1.6862 mL	8.4310 mL
20 mM	0.0843 mL	0.4215 mL	0.8431 mL	4.2155 mL
50 mM	0.0337 mL	0.1686 mL	0.3372 mL	1.6862 mL
100 mM	0.0169 mL	0.0843 mL	0.1686 mL	0.8431 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Citations

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc