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Kobusin, a bisepoxylignan compound isolated from Pnonobio biondii Pamp, demonstrates CFTR and CaCC chloride channel activation properties while exhibiting inhibitory effects on ANO1/CaCC channels.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $105 | In Stock | |
5 mg | $231 | In Stock | |
10 mg | $382 | In Stock | |
25 mg | $636 | In Stock | |
50 mg | $908 | In Stock |
Description | Kobusin, a bisepoxylignan compound isolated from Pnonobio biondii Pamp, demonstrates CFTR and CaCC chloride channel activation properties while exhibiting inhibitory effects on ANO1/CaCC channels. |
In vivo | Methods: HT-29 cells were treated with kobusin (0.1-1000 μM) to investigate the endogenous expression of CFTR and CaCCs in HT-29 cells and short-circuit current assays were performed to investigate the activation induced by kobusin and eudesmin. Results: Kobusin increased CFTR-mediated short-circuit currents in a dose-dependent manner. In the presence of 100 nM FSK, kobusin induced more robust CFTR-mediated short-circuit currents. [2] |
Molecular Weight | 370.4 |
Formula | C21H22O6 |
Cas No. | 36150-23-9 |
Smiles | O(C)C=1C=C([C@@H]2[C@@]3([C@@]([C@H](OC3)C=4C=C5C(=CC4)OCO5)(CO2)[H])[H])C=CC1OC |
Relative Density. | 1.265 g/cm3 (Predicted) |
Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (215.98 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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