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INCB3619
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Catalog No. T27603Cas No. 791826-72-7
Alias INCB-3619, INCB 3619
INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.
INCB3619
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Purity: 99.51%
Catalog No. T27603Alias INCB-3619, INCB 3619Cas No. 791826-72-7
INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $175 | - | In Stock | |
| 5 mg | $438 | - | In Stock | |
| 10 mg | $619 | - | In Stock | |
| 25 mg | Preferential | - | In Stock | |
| 50 mg | Preferential | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.51%
ee:100%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15. |
| Targets&IC50 | Heregulin:0.24 μM |
| In vitro | The dual ADAM inhibitor INCB3619 inhibits heregulin cleavage with an IC50 value of 0.24 μM[1].Treating A549 cells in serum-free culture with varying concentrations of gefitinib and INCB3619 (2-10 µM) for 96 hours revealed that INCB3619 sensitizes A549 cells to gefitinib[1]. |
| In vivo | INCB3619 was administered subcutaneously using ALZET osmotic pumps at doses of 30 or 60 mg/kg/day for 14 days. The results showed that the ADAM inhibitor INCB3619 inhibited gefitinib-resistant HER3 autocrine mechanism, exerting antitumor activity in vivo, and sensitizing tumors to chemotherapy drugs[1]. |
| Synonyms | INCB-3619, INCB 3619 |
| Molecular Weight | 413.47 |
| Formula | C22H27N3O5 |
| Cas No. | 791826-72-7 |
| Smiles | C(NO)(=O)[C@H]1CC2(CN(C(OC)=O)[C@@H]1C(=O)N3CCC(=CC3)C4=CC=CC=C4)CC2 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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