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MMV009085

Name: MMV009085
Brand: TargetMol
SKU: T78184
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78184 Copy Product Info

Purity: 99.66%

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MMV009085 is a highly selective inhibitor of Plasmodium falciparum hexose transporter 1 (PfHT1) that effectively blocks glucose uptake by the parasite (IC₅₀ = 2.6 μM), thereby inhibiting the in vitro growth of the Plasmodium falciparum 3D7 strain.

Cas No. 298217-59-1

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Pack Size	Price	USA Stock	Global Stock
1 mg	$50	-	In Stock
5 mg	$113	-	In Stock
10 mg	$185	-	In Stock
25 mg	$297	-	In Stock
50 mg	$463	-	In Stock
100 mg	$667	-	In Stock
1 mL x 10 mM (in DMSO)	$126	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.66%

Appearance:Solid

Color:Pink

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COA HNMR LCMS

Product Introduction

Bioactivity

Description

In vitro

MMV009085 exhibits an inhibitory effect on PfHT-1 transport activity with an IC50 value of 212±39 μM and suppresses the growth of 3D7 and Dd2 strains with EC50 values of 1.23±0.04 μM and 0.720±0.05 μM, respectively. MMV009085's cytotoxicity in HEK293T and HepG2 cells is demonstrated by CC50 values of 2.46±0.03 μM and 1.92±0.85 μM, respectively [1]. Additionally, in glucose uptake assays with free parasites, MMV009085 shows an IC50 of 2.6 μM. In vitro, it inhibits the growth of the malaria parasite 3D7 with an EC50 of 0.987 μM and impedes parasite growth through PfHT blockade (EC50 = 0.795 μM) [1].

Chemical Properties

Molecular Weight	410.42
Formula	C₂₂H₂₂N₂O₆
Cas No.	298217-59-1
Smiles	O=C1C2=CC=C3C(=O)N(C(=O)C4=CC=C(C(=O)N1CCCCO)C2=C34)CCCCO

Storage & Solubility Information

Storage

Keep away from moisture,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (194.92 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4365 mL	12.1826 mL	24.3653 mL	121.8264 mL
5 mM	0.4873 mL	2.4365 mL	4.8731 mL	24.3653 mL
10 mM	0.2437 mL	1.2183 mL	2.4365 mL	12.1826 mL
20 mM	0.1218 mL	0.6091 mL	1.2183 mL	6.0913 mL
50 mM	0.0487 mL	0.2437 mL	0.4873 mL	2.4365 mL
100 mM	0.0244 mL	0.1218 mL	0.2437 mL	1.2183 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: MMV009085 chemical structure | MMV009085 in vitro | MMV009085 formula | MMV009085 molecular weight