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OF-1

🥰Excellent
Catalog No. T2127Cas No. 919973-83-4

OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.

OF-1

OF-1

🥰Excellent
Purity: 98.55%
Catalog No. T2127Cas No. 919973-83-4
OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$32In StockIn Stock
5 mg$72In StockIn Stock
10 mg$132In StockIn Stock
25 mg$267In StockIn Stock
50 mg$428In StockIn Stock
100 mg$662In StockIn Stock
200 mg$926-In Stock
1 mL x 10 mM (in DMSO)$72In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:98.55%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.
Targets&IC50
BRPF2:500 nM(Kd), BRPF1B:100 nM(Kd)
In vitro
As a chemical probe for BRPF bromodomains, OF-1 increases thermal stability in the cellular thermal shift assay of full length BRPF1B at 1 μM and also demonstrates accelerated FRAP recovery at 5 μM in the BRPF2 FRAP assay. In addition, OF-1 shows modest general cytotoxicity. [1]
Chemical Properties
Molecular Weight440.31
FormulaC17H18BrN3O4S
Cas No.919973-83-4
SmilesCOc1cc2n(C)c(=O)n(C)c2cc1NS(=O)(=O)c1ccc(Br)cc1C
Relative Density.1.557 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 8.8 mg/mL (19.99 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.27 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2711 mL11.3556 mL22.7113 mL113.5564 mL
5 mM0.4542 mL2.2711 mL4.5423 mL22.7113 mL
10 mM0.2271 mL1.1356 mL2.2711 mL11.3556 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

OF-1OF1OF 1InhibitorinhibitEpigeneticReaderDomainEpigenetic Reader DomainBRPF2BRPF1B
Related Tags: buy OF-1 | purchase OF-1 | OF-1 cost | order OF-1 | OF-1 chemical structure | OF-1 in vitro | OF-1 formula | OF-1 molecular weight
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