NVP-DPP728 dihydrochloride

Name: NVP-DPP728 dihydrochloride
Brand: TargetMol
SKU: T39481
Rating: 4.5 (1 reviews)

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Catalog No. T39481Cas No. 207556-62-5

Alias NVP-DPP728 dihydrochloride

NVP-DPP728 dihydrochloride is a highly potent, selective, and orally active inhibitor of dipeptidyl peptidase IV (DPP-IV), with a binding affinity (K i ) of 11 nM. This compound proves useful for investigating diabetes mellitus in research studies.

NVP-DPP728 dihydrochloride

😃Good

Catalog No. T39481Alias NVP-DPP728 dihydrochlorideCas No. 207556-62-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$1,520	Inquiry	Inquiry

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Product Introduction

Bioactivity

Description	NVP-DPP728 dihydrochloride is a highly potent, selective, and orally active inhibitor of dipeptidyl peptidase IV (DPP-IV), with a binding affinity (K i ) of 11 nM. This compound proves useful for investigating diabetes mellitus in research studies.
Targets&IC50	DPP4:11 nM (Ki)
In vitro	NVPDPP728 selectively inhibits DPP-IV in both human and rat plasma, exhibiting high potency with IC50 values between 5-10 nM. Its selectivity exceeds 15,000-fold compared to DPP-II and various proline-cleaving proteases[1].
In vivo	NVP-DPP728 (3.72 mg/kg; p.o.) suppresses DPP-IV, likely amplify ng endogenous GLP-1 effects to enhance insulin secretion and glucose tolerance in obese (fa/fa) and lean (FA/?) Zucker rats, as evidenced by inhibited plasma DPP-IV activity.
Synonyms	NVP-DPP728 dihydrochloride

Chemical Properties

Molecular Weight	371.27
Formula	C₁₅H₂₀Cl₂N₆O
Cas No.	207556-62-5
Smiles	Cl.Cl.O=C(CNCCNc1ccc(cn1)C#N)N1CCC[C@H]1C#N

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc