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NVP-DPP728 dihydrochloride

Catalog No. T39481 CAS 207556-62-5

Synonyms: NVP-DPP728 dihydrochloride

NVP-DPP728 dihydrochloride is a highly potent, selective, and orally active inhibitor of dipeptidyl peptidase IV (DPP-IV), with a binding affinity (K i ) of 11 nM. This compound proves useful for investigating diabetes mellitus in research studies.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

NVP-DPP728 dihydrochloride Chemical Structure

NVP-DPP728 dihydrochloride, CAS 207556-62-5

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25 mg	Inquiry	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	NVP-DPP728 dihydrochloride is a highly potent, selective, and orally active inhibitor of dipeptidyl peptidase IV (DPP-IV), with a binding affinity (K i ) of 11 nM. This compound proves useful for investigating diabetes mellitus in research studies.
Targets&IC50	DPP4:11 nM (Ki)
In vitro	NVPDPP728 selectively inhibits DPP-IV in both human and rat plasma, exhibiting high potency with IC50 values between 5-10 nM. Its selectivity exceeds 15,000-fold compared to DPP-II and various proline-cleaving proteases[1].
In vivo	NVP-DPP728 (3.72 mg/kg; p.o.) suppresses DPP-IV, thereby enhancing insulin secretion and glucose tolerance, likely by amplifying endogenous GLP-1 effects in obese (fa/fa) and lean (FA/?) Zucker rats. The study utilized an oral dosage of 3.72 mg/kg, resulting in the inhibition of plasma DPP-IV activity.

Synonyms	NVP-DPP728 dihydrochloride
Molecular Weight	371.27
Formula	C15H20Cl2N6O
CAS No.	207556-62-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. T E Hughes, et al. NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)- pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV. Biochemistry. 1999 Sep 7;38(36):11597-603. 2. B Balkan, et al. Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats. Diabetologia. 1999 Nov;42(11):1324-31.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

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