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Bufexamac

Name: Bufexamac
Brand: TargetMol
SKU: T0867
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0867Cas No. 2438-72-4

Alias Bufexamic acid

Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.

Bufexamac

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Purity: 99.73%

Catalog No. T0867Alias Bufexamic acidCas No. 2438-72-4

Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$29	In Stock	In Stock
200 mg	$38	In Stock	In Stock
500 mg	$52	-	In Stock
1 g	$75	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.73%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.
Targets&IC50	HDAC3:341 μM (Kd app), HDAC6:10.7 μM (Kd app), HDAC8:235 μM (Kd app), HDAC10:12.3 μM (Kd app), IFN-α:8.9 μM
In vitro	Bufexamac is a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Treatment of peripheral blood mononuclear cells with bufexamac inhibits the secretion of IFN-α. [1] Bufexamac is a frequent and relevant contact sensitizer. Bufexamac is a non-steroidal anti-inflammatory drug. [2]
Synonyms	Bufexamic acid

Chemical Properties

Molecular Weight	223.27
Formula	C₁₂H₁₇NO₃
Cas No.	2438-72-4
Smiles	C(C(NO)=O)C1=CC=C(OCCCC)C=C1
Relative Density.	1.1223 g/cm3 (Estimated)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 3 mg/mL (13.44 mM), Sonication is recommended.

DMSO: 70 mg/mL (313.52 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4789 mL	22.3944 mL	44.7888 mL	223.9441 mL
5 mM	0.8958 mL	4.4789 mL	8.9578 mL	44.7888 mL
10 mM	0.4479 mL	2.2394 mL	4.4789 mL	22.3944 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.2239 mL	1.1197 mL	2.2394 mL	11.1972 mL
50 mM	0.0896 mL	0.4479 mL	0.8958 mL	4.4789 mL
100 mM	0.0448 mL	0.2239 mL	0.4479 mL	2.2394 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc