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MC3482

Name: MC3482
Brand: TargetMol
SKU: T11962
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11962Cas No. 2922280-86-0

MC3482 is a specific inhibitor of sirtuin5 (SIRT5).

MC3482

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Purity: 99.90%

Catalog No. T11962Cas No. 2922280-86-0

MC3482 is a specific inhibitor of sirtuin5 (SIRT5).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
2 mg	$68	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$189	In Stock	In Stock
25 mg	$297	In Stock	In Stock
50 mg	$469	In Stock	In Stock
100 mg	$762	-	In Stock
500 mg	$1,530	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.90%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	MC3482 is a specific inhibitor of sirtuin5 (SIRT5).
In vitro	MC3482 selectively inhibits the desuccinylating activity of sirtuin5 (SIRT5) at a concentration of 50 μM, without altering SIRT5's intracellular expression levels. Both autophagy and mitophagy are enhanced in cells with silenced SIRT5 and in wild-type cells treated with MC3482, whereas these processes are diminished in cells overexpressing SIRT5[1].

Chemical Properties

Molecular Weight	618.68
Formula	C₃₃H₃₈N₄O₈
Cas No.	2922280-86-0
Smiles	[C@H](C(NC1=CC=CC=C1)=O)(NC(OCC2=CC=CC=C2)=O)CCCCNC(CC[C@H](NC(OCC3=CC=CC=C3)=O)C(O)=O)=O
Relative Density.	1.277 g/cm3 at 20℃ (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 145 mg/mL (234.37 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (6.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6163 mL	8.0817 mL	16.1634 mL	80.8172 mL
5 mM	0.3233 mL	1.6163 mL	3.2327 mL	16.1634 mL
10 mM	0.1616 mL	0.8082 mL	1.6163 mL	8.0817 mL
20 mM	0.0808 mL	0.4041 mL	0.8082 mL	4.0409 mL
50 mM	0.0323 mL	0.1616 mL	0.3233 mL	1.6163 mL
100 mM	0.0162 mL	0.0808 mL	0.1616 mL	0.8082 mL

Calculator

Molarity Calculator
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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc