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Laminaran

Name: Laminaran
Brand: TargetMol
SKU: T15705
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15705Cas No. 9008-22-4

Alias β-1,3-Glucan

Laminaran is a β-1,3-glucan isolated from brown algae, often serving as a typical ligand for Dectin-1. It possesses anti-cancer, immune-modulating, and radiation-protective properties. Laminaran can be catalyzed by glucanase. In in vitro and in vivo experiments, Laminaran has demonstrated anti-tumor activity and may be used for severe cancers.

Laminaran

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Catalog No. T15705Alias β-1,3-GlucanCas No. 9008-22-4

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$39	In Stock	In Stock
500 mg	$91	-	In Stock
1 g	$129	-	In Stock
2 g	$192	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Laminaran is a β-1,3-glucan isolated from brown algae, often serving as a typical ligand for Dectin-1. It possesses anti-cancer, immune-modulating, and radiation-protective properties. Laminaran can be catalyzed by glucanase. In in vitro and in vivo experiments, Laminaran has demonstrated anti-tumor activity and may be used for severe cancers.
In vitro	Laminaran ( 100-800μg / mL ; 24 h ) had no cytotoxicity to normal epidermal cells JB6 Cl41 and human melanoma cells SK-MEL-28. After 15 hours of treatment, the inhibition percentage of the number of living cells was less than 24 % when the concentration was up to 800μg / mL [ 1 ]. Kelp glycan ( 200μg / mL ; 24-72 hours ) did not induce any growth inhibition of SK-MEL-48 cells after treatment for 28 hours and 24 hours. However, it reduced cell proliferation by 72 % after 36 hours of treatment [ 1 ]. Low concentration of kelp glycan ( 25-50μg / mL ; 24 h ) did not affect the phosphorylation of c-Raf ( Ser259 ), ERK1 / 2 ( Tyr202 / Tyr204 ) and MEK1 / 2 ( Ser 221 ) kinases, as well as the total expression level of the studied proteins. However, it reduced p-MEK and p-ERK2 / 50 at 1 μg / mL [ 1 ].
In vivo	Compared with PBS-, OVA-and kelp protein-treated mice, Laminaran ( intravenous injection ; 12.5,25 and 50 mg / kg ; 21 days ) and OVA ( 50μg ) combination significantly reduced tumor mass [ 2 ].
Synonyms	β-1,3-Glucan

Chemical Properties

Molecular Weight	504.438
Formula	C₁₈H₃₂O₁₆
Cas No.	9008-22-4
Smiles	OC[C@H]1OC(O[C@H]2[C@H](O)[C@@H](CO)OC(O[C@@H]3[C@@H](O)C(O)O[C@H](CO)[C@H]3O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 29.41 mg/mL (58.3 mM), Sonication is recommended.

DMSO: < 1 mg/mL (insoluble or slightly soluble), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.9824 mL	9.9120 mL	19.8240 mL	99.1202 mL
5 mM	0.3965 mL	1.9824 mL	3.9648 mL	19.8240 mL
10 mM	0.1982 mL	0.9912 mL	1.9824 mL	9.9120 mL
20 mM	0.0991 mL	0.4956 mL	0.9912 mL	4.9560 mL
50 mM	0.0396 mL	0.1982 mL	0.3965 mL	1.9824 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc