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Anti-Complement C5a Antibody-HRP (1C670)

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Catalog No. TMAY-01017H
Alias complement component 5

Anti-Complement C5a Antibody-HRP (1C670) is a HRP-conjugated Mouse antibody targeting Complement C5a. Anti-Complement C5a Antibody-HRP (1C670) can be used in ELISA.

Anti-Complement C5a Antibody-HRP (1C670)

Anti-Complement C5a Antibody-HRP (1C670)

😃Good
Catalog No. TMAY-01017HAlias complement component 5
Anti-Complement C5a Antibody-HRP (1C670) is a HRP-conjugated Mouse antibody targeting Complement C5a. Anti-Complement C5a Antibody-HRP (1C670) can be used in ELISA.
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100 μg$292 7-10 days
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Product Introduction

Bioactivity
Description
Anti-Complement C5a Antibody-HRP (1C670) is a HRP-conjugated Mouse antibody targeting Complement C5a. Anti-Complement C5a Antibody-HRP (1C670) can be used in ELISA.
Aliascomplement component 5
Ig Type
Monoclonal Mouse IgG1
Clone
1C670
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 0.1-1 μg/ml
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human C5a (rh C5a; TMPY-00653; NP_001726.2; Leu679-Arg751). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with horseradish-peroxidase (HRP).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundC5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathways of complement activation. The structure of C5a includes a core region consisting of four, anti-parallel alpha-helices held together by three disulfide linkages and a structured C-terminal tail, and C5a is rapidly metabolised by carboxypeptidase B to a 73 amino acid low activity form, C5a des-Arg. C5a is an extremely potent proinflammatory mediator, as well as a potent chemotactic factor for neutrophils and other leukocytes. It causes histamine release, increases in vascular permeability, induces several cytokines production from leukocytes, enhances neutrophil-endothelial cell adhesion, and augments the humoral and cell-mediated immune response. C5a is quickly metabolised by carboxypeptidases, forming the less potent C5adesArg. Acting via a classical G protein-coupled receptor, CD88, C5a and C5adesArg exert a number of effects essential to the innate immune response, while their actions at the more recently discovered non-G protein-coupled receptor, C5L2 (or GPR77), remain unclear. The widespread expression of C5a receptors throughout the body allows C5a to elicit a broad range of effects. Thus, C5a has been found to be a significant pathogenic driver in a number of immuno-inflammatory diseases, making C5a inhibition an attractive therapeutic strategy. C5a is a strong chemoattractant and is involved in the recruitment of inflammatory cells such as neutrophils, eosinophils, monocytes, and T lymphocytes, in activation of phagocytic cells and release of granule-based enzymes and generation of oxidants, all of which may contribute to innate immune functions or tissue damage. Accordingly, the anaphylatoxin C5a is implicated in a variety of diseases such as rheumatoid arthritis, systemic lupus erythematosus, reperfusion injury, Alzheimer's disease, and sepsis.
Related Conjugates and Formulations
Conjucates
HRP
Others Formats
Unconjugated
Antibody Types Available
2
Antigen Details
Immunogen
Recombinant Human C5a Protein (TMPY-00653)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. Keep away from direct sunlight.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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