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YM-53601

Name: YM-53601
Brand: TargetMol
SKU: T26345
Price: 163 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26345Cas No. 182959-33-7

Alias YM53601, YM 53601

YM-53601 is a potent squalene synthase (SQS) inhibitor that inhibits adipogenic biosynthesis and lipid secretion in rodents.YM-53601 is a cholesterol-lowering agent that inhibits farnesyl diphosphate farnesyltransferase 1 (FDFT1).YM-53601 exhibits potential antiviral activity and enhances adriamycin-mediated HCC arrest and cell death in vivo. MJN228 is a lipid-based enzyme.

YM-53601

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Purity: 99.65%

Catalog No. T26345Alias YM53601, YM 53601Cas No. 182959-33-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$163	In Stock	In Stock
5 mg	$413	In Stock	In Stock
10 mg	$662	-	In Stock
25 mg	$1,320	-	In Stock
50 mg	$2,150	-	In Stock
1 mL x 10 mM (in DMSO)	$455	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.65%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	YM-53601 is a potent squalene synthase (SQS) inhibitor that inhibits adipogenic biosynthesis and lipid secretion in rodents.YM-53601 is a cholesterol-lowering agent that inhibits farnesyl diphosphate farnesyltransferase 1 (FDFT1).YM-53601 exhibits potential antiviral activity and enhances adriamycin-mediated HCC arrest and cell death in vivo. MJN228 is a lipid-based enzyme.
Targets&IC50	Squalene synthase (hamster liver):170 nM, HepG2 cells (guinea pig liver microsomes):46 nM, HepG2 cells (rhesus monkey liver microsomes):45 nM, HepG2 cells (human liver microsomes):79 nM, HepG2 cells (rat liver microsomes):90 nM, HepG2 cells (hamster liver microsomes):170 nM
In vitro	YM-53601 inhibited squalene synthase activity in a variety of animal and human cell lines, with IC50s of 90, 170, 46, 45, and 79 nM in liver microsomes of rat, hamster, guinea pig, rhesus monkey, and human HepG2 cells, respectively. [1] YM-53601 inhibited the conversion of [3H] farnesyl diphosphate to [3H] squalene by squalene synthase in hamster liver with an IC50 of 170 nM. [2] In H35 cells, 1 μM M-53601 enhanced sensitivity to toxic carotenoids, lonidamine and adriamycin, and reduced mitochondrial cholesterol levels in H35 and HepG2 cells. [4]
In vivo	YM-53601 inhibited cholesterol biosynthesis in rats at an ED50 of 32 mg/kg . [1] In addition, in a hamster model, YM-53601 reduced plasma non-HDL cholesterol levels by approximately 70% when administered orally at 50 mg/kg/day for 5 days. [2] YM-53601 also enhanced doxorubicin-mediated inhibition of hepatocellular carcinoma (HCC) cell proliferation and cell death in vivo. [4]
Synonyms	YM53601, YM 53601

Chemical Properties

Molecular Weight	372.86
Formula	C₂₁H₂₂ClFN₂O
Cas No.	182959-33-7
Smiles	O(C/C(/F)=C\1/C2CCN(C1)CC2)C=3C=C4C(C=5C(N4)=CC=CC5)=CC3.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (214.56 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (8.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6820 mL	13.4099 mL	26.8197 mL	134.0986 mL
5 mM	0.5364 mL	2.6820 mL	5.3639 mL	26.8197 mL
10 mM	0.2682 mL	1.3410 mL	2.6820 mL	13.4099 mL
20 mM	0.1341 mL	0.6705 mL	1.3410 mL	6.7049 mL
50 mM	0.0536 mL	0.2682 mL	0.5364 mL	2.6820 mL
100 mM	0.0268 mL	0.1341 mL	0.2682 mL	1.3410 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc