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PD-166793

Name: PD-166793
Brand: TargetMol
SKU: T20563
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20563Cas No. 199850-67-4

Alias PD-166793-0000, PD166793, PD 166793

PD-166793 is an orally active, potent and selective MMP inhibitor with inhibitory effects on MMP-2, MMP-3 and MMP-13.PD-166793 ameliorates myocardial ischemia and reperfusion injury in a rat model of heart failure.PD-166793 is an orally active, potent and selective MMP inhibitor with inhibitory effects on MMP-2, MMP-3, and MMP-13.

PD-166793

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Purity: 99.86%

Catalog No. T20563Alias PD-166793-0000, PD166793, PD 166793Cas No. 199850-67-4

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$37	In Stock	In Stock
10 mg	$58	In Stock	In Stock
25 mg	$121	In Stock	In Stock
50 mg	$195	In Stock	In Stock
100 mg	$291	In Stock	In Stock
200 mg	$408	-	In Stock
1 mL x 10 mM (in DMSO)	$41	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.86%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	PD-166793 is an orally active, potent and selective MMP inhibitor with inhibitory effects on MMP-2, MMP-3 and MMP-13.PD-166793 ameliorates myocardial ischemia and reperfusion injury in a rat model of heart failure.PD-166793 is an orally active, potent and selective MMP inhibitor with inhibitory effects on MMP-2, MMP-3, and MMP-13.
Targets&IC50	MMP1:6.0 μM, MMP2:4 nM, MMP3:7 nM, MMP9:7.9 μM, MMP13:8 nM, MMP7:7.2 μM
In vitro	In rat heart homogenates, PD-166793 at a concentration of 0.1 μM results in a 20% inhibition of AMP deaminase (AMPD) activity[2]. Additionally, when normal human cardiac fibroblasts are treated with PD-166793 at a concentration of 100 μM for 36 hours, there is a significant reduction in MMP‐9 activity[1].
In vivo	Administered at a dosage of 1 mg/kg per day through daily gavage for a duration of 10 weeks, PD-166793 largely prevents the adverse remodeling typically observed in the aortocaval (AV) fistula model[3]. Furthermore, in rats, PD-166793 administered at a dose of 5 mg/kg via oral gavage demonstrates superior pharmacokinetics, with a half-life (t1/2) of 43.6 hours, a maximum concentration (Cmax) of 42.4 µg/mL, and an area under the curve from 0 to infinity (AUC0-∞) of 2822 µg•h/mL[2].
Synonyms	PD-166793-0000, PD166793, PD 166793

Chemical Properties

Molecular Weight	412.3
Formula	C₁₇H₁₈BrNO₄S
Cas No.	199850-67-4
Smiles	CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O
Relative Density.	1.457 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (109.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4254 mL	12.1271 mL	24.2542 mL	121.2709 mL
5 mM	0.4851 mL	2.4254 mL	4.8508 mL	24.2542 mL
10 mM	0.2425 mL	1.2127 mL	2.4254 mL	12.1271 mL
20 mM	0.1213 mL	0.6064 mL	1.2127 mL	6.0635 mL
50 mM	0.0485 mL	0.2425 mL	0.4851 mL	2.4254 mL
100 mM	0.0243 mL	0.1213 mL	0.2425 mL	1.2127 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc