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E-7386

Name: E-7386
Brand: TargetMol
SKU: T11136
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T11136Cas No. 1799824-08-0

Alias E7386

E-7386 is an oral active CBP/ -catenin modulator.

E-7386

😃Good

Purity: 99.91%

Catalog No. T11136Alias E7386Cas No. 1799824-08-0

E-7386 is an oral active CBP/ -catenin modulator.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$89	In Stock	In Stock
2 mg	$137	In Stock	In Stock
5 mg	$243	In Stock	In Stock
10 mg	$396	In Stock	In Stock
25 mg	$682	In Stock	In Stock
50 mg	$969	In Stock	In Stock
100 mg	$1,290	-	In Stock
1 mL x 10 mM (in DMSO)	$389	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	E-7386 is an oral active CBP/ -catenin modulator.
In vivo	E-7386 is an oral active CBP/ -catenin regulator, which can induce T cells to infiltrate into the tumor in the Wnt1 tumor cogene mouse model and enhance the anti-tumor activity of anti-PD-1 monoclonal antibody.In the Wnt1 model, t-cell infiltration in the vehicle control group was limited, while t-cell infiltration in the E-7386 treatment group was obvious, and E-7386 showed significant anti-tumor activity.
Synonyms	E7386

Chemical Properties

Molecular Weight	725.85
Formula	C₃₉H₄₈FN₉O₄
Cas No.	1799824-08-0
Smiles	[H][C@]12CN(Cc3cccc(n3)N3CC(C3)N3CCN(CC)CC3)C(=O)[C@H](Cc3ccc(O)cc3F)N1C(=O)CN(CC=C)N2C(=O)NCc1ccccc1
Relative Density.	1.39 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Methanol: 250 mg/mL (344.42 mM), Sonication is recommended.

DMSO: 125 mg/mL (172.21 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (5.51 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Methanol

	1mg	5mg	10mg	50mg
1 mM	1.3777 mL	6.8885 mL	13.7770 mL	68.8848 mL
5 mM	0.2755 mL	1.3777 mL	2.7554 mL	13.7770 mL
10 mM	0.1378 mL	0.6888 mL	1.3777 mL	6.8885 mL
20 mM	0.0689 mL	0.3444 mL	0.6888 mL	3.4442 mL
50 mM	0.0276 mL	0.1378 mL	0.2755 mL	1.3777 mL
100 mM	0.0138 mL	0.0689 mL	0.1378 mL	0.6888 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc