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Mitazalimab
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Catalog No. T77090Cas No. 2055640-86-1
Alias JNJ7107, JNJ-64457107, JNJ64457107, JNJ 7107, ADC-1013, AD-1013
Mitazalimab (ADC-1013) is a monoclonal IgG antibody targeting CD40 and a CD40 agonist with antitumor activity. Mitazalimab activates antigen-presenting cells, induces transient peripheral transcriptome changes, and can be used to study tumors.
Mitazalimab
Mitazalimab
😃Good
Catalog No. T77090Alias JNJ7107, JNJ-64457107, JNJ64457107, JNJ 7107, ADC-1013, AD-1013Cas No. 2055640-86-1
Mitazalimab (ADC-1013) is a monoclonal IgG antibody targeting CD40 and a CD40 agonist with antitumor activity. Mitazalimab activates antigen-presenting cells, induces transient peripheral transcriptome changes, and can be used to study tumors.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $247 | In Stock | In Stock | |
| 5 mg | $645 | In Stock | In Stock | |
| 10 mg | $987 | - | In Stock | |
| 25 mg | $1,530 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock | |
| 100 mg | $2,790 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:95.1% (SDS-PAGE); 98.7% (SEC-HPLC)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Antibody Information
| Description | Mitazalimab (ADC-1013) is a monoclonal IgG antibody targeting CD40 and a CD40 agonist with antitumor activity. Mitazalimab activates antigen-presenting cells, induces transient peripheral transcriptome changes, and can be used to study tumors. |
| In vitro | Mitazalimab (1 ng/mL-10 μg/mL) was able to activate tumor-associated macrophages (TAM) in human prostate or ovarian cancer samples. [2] |
| In vivo | Mitazalimab (100 μg/mouse, intraperitoneal injection, single dose) was able to activate splenic dendritic cells and B-cells in naïve hCD40tg mice and induced OVA-specific CD8+ T-cell expansion under OVA reprocessing conditions (200 μg intravenously, 3 times over 7 consecutive days). In addition, Mitazalimab (100 and 300 μg/mouse, intraperitoneal injection, administered on days 7, 10, and 13 post-inoculation) induced the release of pro-inflammatory cytokines and chemokines in the blood of animals bearing bladder tumors in MB49 mice and affected the composition of tumor bone marrow cells, resulting in a decrease in monocytes and macrophages and an increase in the number of granulocytes. [1] |
| Synonyms | JNJ7107, JNJ-64457107, JNJ64457107, JNJ 7107, ADC-1013, AD-1013 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | TNFRSF5/CD40 |
| Molecular Weight | 143.42 kDa |
| Cas No. | 2055640-86-1 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG1 lambda2 |
| Recommended Isotype Control |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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