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Mitazalimab (Synonyms: JNJ7107, JNJ-64457107, JNJ64457107, JNJ 7107, ADC-1013, AD-1013)
Catalog No. T77090 Copy Product Info
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Mitazalimab (ADC-1013) is a monoclonal IgG antibody targeting CD40 and a CD40 agonist with antitumor activity. Mitazalimab activates antigen-presenting cells, induces transient peripheral transcriptome changes, and can be used to study tumors.
Mitazalimab
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Catalog No. T77090
Synonyms JNJ7107, JNJ-64457107, JNJ64457107, JNJ 7107, ADC-1013, AD-1013
Mitazalimab (ADC-1013) is a monoclonal IgG antibody targeting CD40 and a CD40 agonist with antitumor activity. Mitazalimab activates antigen-presenting cells, induces transient peripheral transcriptome changes, and can be used to study tumors.
Mitazalimab
Cas No. 2055640-86-1
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $247 | In Stock | In Stock | |
| 5 mg | $645 | In Stock | In Stock | |
| 10 mg | $987 | - | In Stock | |
| 25 mg | $1,530 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock | |
| 100 mg | $2,790 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:95.1% (SDS-PAGE); 98.7% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Mitazalimab (ADC-1013) is a monoclonal IgG antibody targeting CD40 and a CD40 agonist with antitumor activity. Mitazalimab activates antigen-presenting cells, induces transient peripheral transcriptome changes, and can be used to study tumors. |
| In vitro | Mitazalimab (1 ng/mL-10 μg/mL) was able to activate tumor-associated macrophages (TAM) in human prostate or ovarian cancer samples. [2] |
| In vivo | Mitazalimab (100 μg/mouse, intraperitoneal injection, single dose) was able to activate splenic dendritic cells and B-cells in naïve hCD40tg mice and induced OVA-specific CD8+ T-cell expansion under OVA reprocessing conditions (200 μg intravenously, 3 times over 7 consecutive days). In addition, Mitazalimab (100 and 300 μg/mouse, intraperitoneal injection, administered on days 7, 10, and 13 post-inoculation) induced the release of pro-inflammatory cytokines and chemokines in the blood of animals bearing bladder tumors in MB49 mice and affected the composition of tumor bone marrow cells, resulting in a decrease in monocytes and macrophages and an increase in the number of granulocytes. [1] |
| Synonyms | JNJ7107, JNJ-64457107, JNJ64457107, JNJ 7107, ADC-1013, AD-1013 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | TNFRSF5/CD40 |
| Molecular Weight | 143.42 kDa |
| Cas No. | 2055640-86-1 |
| Isotype | Human IgG1 lambda2 |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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