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L-Homocysteic acid (Synonyms: L-HCA)

Name: L-Homocysteic acid
Brand: TargetMol
SKU: T74129
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T74129 Copy Product Info

Purity: 99.82%

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L-Homocysteic acid is an endogenous excitatory amino acid that acts as an NMDA receptor agonist with an EC50 of 14 μM. L-Homocysteic acid is neurotoxic and can be used in neurological disease-related research.

L-Homocysteic acid

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Catalog No. T74129

Synonyms L-HCA

Cas No. 14857-77-3

Pack Size	Price	USA Stock	Global Stock	Quantity
5 mg	$40	-	In Stock
10 mg	Preferential	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.82%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	L-Homocysteic acid is an endogenous excitatory amino acid that acts as an NMDA receptor agonist with an EC50 of 14 μM. L-Homocysteic acid is neurotoxic and can be used in neurological disease-related research.
Targets&IC50	NMDAR:14 μM (EC50)
In vitro	L-Homocysteic acid activates NMDA receptors with an EC₅₀ of 14 μM. In Purkinje cells, 100 μM L-Homocysteic acid evokes a distinct current with an amplitude of up to 1.8 nA, and this current response cannot be blocked by a combination of NMDA receptor antagonists [1]. At a concentration of 250 μM and a duration of 30 min, L-Homocysteic acid potently induces acute excitotoxic damage in ex vivo chick embryo retinal tissue [2]. In primary rat neuron cultures, treatment with 0–2 mM L-Homocysteic acid for 48 h produces a concentration-dependent neurotoxic effect [3].
In vivo	L-Homocysteic acid (intraperitoneal injection, 4–11 mmol/kg) can induce seizures in early postnatal developing rats [4]. L-Homocysteic acid (intraperitoneal injection, 100–1500 mg/kg) can partially substitute NMDA in Sprague-Dawley rats, producing 61%–67% of the maximum NMDA lever response rate at doses of 1000 mg/kg and 560 mg/kg, respectively [5].
Synonyms	L-HCA

Chemical Properties

Molecular Weight	183.18
Formula	C₄H₉NO₅S
Cas No.	14857-77-3
Smiles	C([C@@H](C(O)=O)N)CS(=O)(=O)O
Sequence	H-Abu(SO3H)(SO3H)-OH
Sequence Short	X

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (436.73 mM)

DMSO: 40 mg/mL (218.36 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	5.4591 mL	27.2956 mL	54.5911 mL	272.9556 mL
5 mM	1.0918 mL	5.4591 mL	10.9182 mL	54.5911 mL
10 mM	0.5459 mL	2.7296 mL	5.4591 mL	27.2956 mL
20 mM	0.2730 mL	1.3648 mL	2.7296 mL	13.6478 mL
50 mM	0.1092 mL	0.5459 mL	1.0918 mL	5.4591 mL
100 mM	0.0546 mL	0.2730 mL	0.5459 mL	2.7296 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc