Shopping Cart
Remove All
Your shopping cart is currently empty
Harmine hydrochloride
Copy Product Info
🥰Excellent
Catalog No. T2811Cas No. 343-27-1
Alias telepathine hydrochloride
Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus.
Harmine hydrochloride
Copy Product Info🥰Excellent
Purity: 99.84%
Catalog No. T2811Alias telepathine hydrochlorideCas No. 343-27-1
Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 mg | $41 | In Stock | In Stock | |
| 100 mg | $66 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.84%
Color:White to Yellow
Contact us for more batch information
Product Introduction
Harmine hydrochloride AI Summary
Harmine hydrochloride exhibits a broad spectrum of bioactivities, implicating its potential for diverse pharmacological applications. It functions as a potent inhibitor of lipid storage modulators, Nrf2, Histone Lysine Methyltransferase G9a, BAZ2B, Human Flap endonuclease 1 (FEN1), and several enzymes linked to DNA repair and cellular signaling such as RAD54, ELG1-dependent DNA repair, and tyrosyl-DNA phosphodiesterase 1 (TDP1). It also displays moderate potency in targeting chronic active B-cell receptor signaling and Schistosoma Mansoni Peroxiredoxins. The compound shows modulatory effects on RanGTP induced Rango and the activity of kallikrein-7 (K7) zymogen.
Additionally, Harmine hydrochloride demonstrates significant inhibitory activity against electric eel acetylcholinesterase (AChE) and horse butyrylcholinesterase (BChE), with inhibition rates of 50.86% and 12.05% respectively at a concentration of 2 mg/ml, indicating potential as a cholinesterase inhibitor. It also exhibits cytotoxicity against human HL cells with an 87.3% activity at 50 µM after 72 hours and showcases antichlamydial activity against Chlamydia pneumoniae K7 infected in HL cells with a 26.0% inhibition rate at 50 µM after 70 hours.
Furthermore, the compound induces genotoxicity in human embryonic kidney cells and DNA re-replication in MCF 10a normal breast cells and SW480 colon adenocarcinoma cells. It inhibits cell surface uPA generation, CF-induced NF-kB activation, and delays death in the malaria parasite plastid. Additionally, Harmine hydrochloride has notable antiviral activity by inhibiting Hepatitis C Virus (HCV) and activates ClpP.
Overall, Harmine hydrochloride's wide range of bioactivities underscores its potential for extensive therapeutic implications and warrants further investigation..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus. |
| Targets&IC50 | MNB:149 nM, DYRK1A:33 nM, 5-HT2A receptor:397 nM (Ki), DYRK2:1.9 μM, DYRK1B:166 nM |
| Synonyms | telepathine hydrochloride |
| Molecular Weight | 248.71 |
| Formula | C13H13ClN2O |
| Cas No. | 343-27-1 |
| Smiles | Cl.COc1ccc2c(c1)[nH]c1c(C)nccc21 |
| Relative Density. | no data available |
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 2 mg/mL (8.04 mM), Sonication is recommended.  | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
| ||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Harmine hydrochloride | purchase Harmine hydrochloride | Harmine hydrochloride cost | order Harmine hydrochloride | Harmine hydrochloride chemical structure | Harmine hydrochloride formula | Harmine hydrochloride molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.