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Necroptosis-IN-1

Name: Necroptosis-IN-1
Brand: TargetMol
SKU: T9305
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9305Cas No. 1391980-92-9

Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.

Necroptosis-IN-1

🥰Excellent

Purity: 99.8%

Catalog No. T9305Cas No. 1391980-92-9

Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.

Pack Size	Price	Availability
1 mg	$58	In Stock
5 mg	$119	In Stock
10 mg	$197	In Stock
25 mg	$335	In Stock
50 mg	$473	In Stock
100 mg	$672	In Stock
200 mg	$885	In Stock
1 mL x 10 mM (in DMSO)	$152	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.8%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.

Chemical Properties

Molecular Weight	263.68
Formula	C₁₂H₁₀ClN₃O₂
Cas No.	1391980-92-9
Smiles	Clc1cccc2c(CC3NC(=O)NC3=O)c[nH]c12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 249 mg/mL (944.32 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7925 mL	18.9624 mL	37.9248 mL	189.6238 mL
5 mM	0.7585 mL	3.7925 mL	7.5850 mL	37.9248 mL
10 mM	0.3792 mL	1.8962 mL	3.7925 mL	18.9624 mL
20 mM	0.1896 mL	0.9481 mL	1.8962 mL	9.4812 mL
50 mM	0.0758 mL	0.3792 mL	0.7585 mL	3.7925 mL
100 mM	0.0379 mL	0.1896 mL	0.3792 mL	1.8962 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc