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Darbufelone

Name: Darbufelone
Brand: TargetMol
SKU: T10960
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10960Cas No. 139226-28-1

Alias CI-1004

Darbufelone (CI-1004) is a non-competitive dual inhibitor of PGF2α and LTB4. Dabfilon effectively inhibits PGHS-2 with a Ki of 10 μM and IC50s of 0.19 μM and 20 μM for PGHS-2 and PGHS-1.

Darbufelone

🥰Excellent

Purity: 99.72%

Catalog No. T10960Alias CI-1004Cas No. 139226-28-1

Darbufelone (CI-1004) is a non-competitive dual inhibitor of PGF2α and LTB4. Dabfilon effectively inhibits PGHS-2 with a Ki of 10 μM and IC50s of 0.19 μM and 20 μM for PGHS-2 and PGHS-1.

Pack Size	Price	Availability
1 mg	$37	In Stock
5 mg	$79	In Stock
10 mg	$133	In Stock
25 mg	$294	In Stock
50 mg	$429	In Stock
100 mg	$592	In Stock
500 mg	$1,180	In Stock
1 mL x 10 mM (in DMSO)	$112	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.72%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Darbufelone (CI-1004) is a non-competitive dual inhibitor of PGF2α and LTB4. Dabfilon effectively inhibits PGHS-2 with a Ki of 10 μM and IC50s of 0.19 μM and 20 μM for PGHS-2 and PGHS-1.
Targets&IC50	PGHS2:0.19 μM , PGHS1:20 μM
In vitro	Darbufelone (5 - 60 μM) increases the cell growth inhibitory effects in A549, H520 and H460 cell lines with IC50s of 20, 21 and 15 μM[2].
In vivo	Darbufelone (80 mg/kg/day) decreases the tumor volumes in a time-dependent manner. Darbufelone (20 or 40 mg/kg/day) dos not show any significant inhibition of tumor weight. At necropsy, Darbufelone (80 mg/kg/day) reduces the tumor weight by 30.2%[2].
Synonyms	CI-1004

Chemical Properties

Molecular Weight	332.46
Formula	C₁₈H₂₄N₂O₂S
Cas No.	139226-28-1
Smiles	C(\C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)=C\2/C(=O)N=C(N)S2
Relative Density.	1.18g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (135.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0079 mL	15.0394 mL	30.0788 mL	150.3940 mL
5 mM	0.6016 mL	3.0079 mL	6.0158 mL	30.0788 mL
10 mM	0.3008 mL	1.5039 mL	3.0079 mL	15.0394 mL
20 mM	0.1504 mL	0.7520 mL	1.5039 mL	7.5197 mL
50 mM	0.0602 mL	0.3008 mL	0.6016 mL	3.0079 mL
100 mM	0.0301 mL	0.1504 mL	0.3008 mL	1.5039 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc