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MK 571

Name: MK 571
Brand: TargetMol
SKU: T7841
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7841Cas No. 115104-28-4

Alias MK-571, L-660711, L660711

MK 571 (L660711) is an orally active antagonist of CysLT1 receptor.

MK 571

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Purity: 99.65%

Catalog No. T7841Alias MK-571, L-660711, L660711Cas No. 115104-28-4

MK 571 (L660711) is an orally active antagonist of CysLT1 receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$78	In Stock	In Stock
25 mg	$177	In Stock	In Stock
50 mg	$317	In Stock	In Stock
100 mg	$479	In Stock	In Stock
200 mg	$686	-	In Stock
1 mL x 10 mM (in DMSO)	$57	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.65%

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	MK 571 (L660711) is an orally active antagonist of CysLT1 receptor.
Targets&IC50	LTE4:10.4 (pA2, in guinea pig ileum), LTD4:2.1 nM (Ki, in human lung), LTD4:0.22 nM (Ki, in guinea pig lung), LTD4:10.5 (pA2, in guinea pig ileum)
In vivo	MK-571 effectively blocks LTD4 activation of recombinant human and murine CysLT1 receptors1,4 but is ineffective at blocking LTC4 or LTD4 activation of the recombinant human or murine CysLT2 receptors[1].
Synonyms	MK-571, L-660711, L660711

Chemical Properties

Molecular Weight	515.09
Formula	C₂₆H₂₇ClN₂O₃S₂
Cas No.	115104-28-4
Smiles	C(=C/C1=CC(C(SCCC(N(C)C)=O)SCCC(O)=O)=CC=C1)\C2=NC3=C(C=C2)C=CC(Cl)=C3
Relative Density.	1.327g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (121.34 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9414 mL	9.7070 mL	19.4141 mL	97.0704 mL
5 mM	0.3883 mL	1.9414 mL	3.8828 mL	19.4141 mL
10 mM	0.1941 mL	0.9707 mL	1.9414 mL	9.7070 mL
20 mM	0.0971 mL	0.4854 mL	0.9707 mL	4.8535 mL
50 mM	0.0388 mL	0.1941 mL	0.3883 mL	1.9414 mL
100 mM	0.0194 mL	0.0971 mL	0.1941 mL	0.9707 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc