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Anti-Nephrin Polyclonal Antibody
(Synonyms: NPHN, nephrosis 1, congenital, Finnish type (nephrin), nephrin, CNF) Copy Product Info
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Synonyms: NPHN, nephrosis 1, congenital, Finnish type (nephrin), nephrin, CNF
Catalog No. TMAB-01214 Copy Product Info
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Anti-Nephrin Polyclonal Antibody is a Rabbit antibody targeting Nephrin. Anti-Nephrin Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P,WB.
Anti-Nephrin Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-Nephrin Polyclonal Antibody is a Rabbit antibody targeting Nephrin. Anti-Nephrin Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P,WB. |
| Synonyms | NPHN, nephrosis 1, congenital, Finnish type (nephrin), nephrin, CNF |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat,Dog (predicted:Rabbit) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1μg/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane; Single-pass type I membrane protein (Potential). Note=Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane. |
| Tissue Specificity | Specifically expressed in podocytes of kidney glomeruli. Expressed in kidney glomeruli. In the embryo,expressed in the mesonephric kidney at E11 with strong expression in cranial tubules with podocyte-like structures. Expression is observed in the podocyt |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.[provided by RefSeq, Oct 2009] |
| Immunogen | KLH conjugated synthetic peptide: human Nephrin |
| Antigen Species | Human |
| Gene Name | NPHS1 |
| Gene ID | |
| Protein Name | Nephrin |
| Uniprot ID | |
| Biology Area | Endothelial |
| Function | Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion. |
| Molecular Weight | Theoretical: 138 kDa. Actual: 138 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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