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Anti-Cortisol Binding Globulin Antibody (6Z799)
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Catalog No. TMAY-01440
Alias SerpinA6, serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 6, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, Cbg, AV104445, AI265318
Anti-Cortisol Binding Globulin Antibody (6Z799) is a Rabbit antibody targeting Cortisol Binding Globulin. Anti-Cortisol Binding Globulin Antibody (6Z799) can be used in ELISA.
Anti-Cortisol Binding Globulin Antibody (6Z799)
Anti-Cortisol Binding Globulin Antibody (6Z799)
😃Good
Catalog No. TMAY-01440Alias SerpinA6, serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 6, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, Cbg, AV104445, AI265318
Anti-Cortisol Binding Globulin Antibody (6Z799) is a Rabbit antibody targeting Cortisol Binding Globulin. Anti-Cortisol Binding Globulin Antibody (6Z799) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
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Antigen Details
Chemical Properties
| Description | Anti-Cortisol Binding Globulin Antibody (6Z799) is a Rabbit antibody targeting Cortisol Binding Globulin. Anti-Cortisol Binding Globulin Antibody (6Z799) can be used in ELISA. |
| Alias | SerpinA6, serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 6, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, Cbg, AV104445, AI265318 |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 6Z799 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinA6 (rh SerpinA6; TMPY-02041; NP_001747.2; Met 1-Val 405). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Corticosteroid-binding globulin (CBG), also known as SerpinA6, is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG, and promotes a significant and local release of glucocorticoids (over 90% of them are bound to CBG in human plasma). In this context, CBG directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable, human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human SerpinA6 protein (TMPY-02041) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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