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Sonrotoclax

Name: Sonrotoclax
Brand: TargetMol
SKU: T74637
Price: 156 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T74637Cas No. 2383086-06-2

Alias BGB 11417

Sonrotoclax is a potent, orally active inhibitor of Bcl2, demonstrating effective cell-killing activity against a range of lymphoma and leukemia cell lines [1].

Sonrotoclax

🥰Excellent

Purity: 99.47%

Catalog No. T74637Alias BGB 11417Cas No. 2383086-06-2

Sonrotoclax is a potent, orally active inhibitor of Bcl2, demonstrating effective cell-killing activity against a range of lymphoma and leukemia cell lines [1].

Pack Size	Price	Availability
1 mg	$156	In Stock
5 mg	$278	In Stock
10 mg	$419	In Stock
25 mg	$637	In Stock
50 mg	$953	In Stock
1 mL x 10 mM (in DMSO)	$412	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.47%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Sonrotoclax is a potent, orally active inhibitor of Bcl2, demonstrating effective cell-killing activity against a range of lymphoma and leukemia cell lines [1].
In vivo	In Female NCG mice with acute lymphoblastic leukemia ( ALL ) xenografts, Sonrotoclax ( 5,15,50 mg / kg ; oral administration ; daily, for 42 days ) can inhibit tumor growth in a dose-dependent manner[1].
Synonyms	BGB 11417

Chemical Properties

Molecular Weight	890.10
Formula	C₄₉H₅₉N₇O₇S
Cas No.	2383086-06-2
Smiles	CC(C1=C(C=CC=C1)[C@H]2N(CCC2)C3CC4(CCN(C5=CC(OC6=CN=C(NC=C7)C7=C6)=C(C=C5)C(NS(=O)(C8=CC([N+]([O-])=O)=C(C=C8)NC[C@@H]9CC[C@@](O)(CC9)C)=O)=O)CC4)C3)C
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (89.88 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (3.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1235 mL	5.6173 mL	11.2347 mL	56.1735 mL
5 mM	0.2247 mL	1.1235 mL	2.2469 mL	11.2347 mL
10 mM	0.1123 mL	0.5617 mL	1.1235 mL	5.6173 mL
20 mM	0.0562 mL	0.2809 mL	0.5617 mL	2.8087 mL
50 mM	0.0225 mL	0.1123 mL	0.2247 mL	1.1235 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc