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BAZ1A-IN-1

🥰Excellent
Catalog No. T9552Cas No. 941521-45-5

BAZ1A-IN-1 is a potent BAZ1A inhibitor with a KD value of 0.52 μM for the BAZ1A bromodomain, demonstrating strong anti-survival activity against cancer cell lines with high BAZ1A expression and weak or no activity against cancer cells with low BAZ1A expression.

BAZ1A-IN-1

BAZ1A-IN-1

🥰Excellent
Purity: 99.87%
Catalog No. T9552Cas No. 941521-45-5
BAZ1A-IN-1 is a potent BAZ1A inhibitor with a KD value of 0.52 μM for the BAZ1A bromodomain, demonstrating strong anti-survival activity against cancer cell lines with high BAZ1A expression and weak or no activity against cancer cells with low BAZ1A expression.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$81In StockIn Stock
5 mg$197In StockIn Stock
10 mg$297In StockIn Stock
25 mg$596In StockIn Stock
50 mg$893In StockIn Stock
100 mg$1,220In StockIn Stock
200 mg$1,630In StockIn Stock
1 mL x 10 mM (in DMSO)$217In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.87%
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Product Introduction

Bioactivity
Description
BAZ1A-IN-1 is a potent BAZ1A inhibitor with a KD value of 0.52 μM for the BAZ1A bromodomain, demonstrating strong anti-survival activity against cancer cell lines with high BAZ1A expression and weak or no activity against cancer cells with low BAZ1A expression.
Targets&IC50
BAZ1A:0.52 μM(Kd), BAZ1A:5.08 μM (THP-1), 4.29 μM(ZR-75-30), 10.65 μM(BT474),7.70 μM(H1975 cells)
In vitro
Administration of BAZ1A-IN-1 (0.015-100?μM; 96 hours) exhibits good anti-viability activity against all the four cancer cell lines that have a high expression level of BAZ1A, with IC50 values of 5.08 μM, 4.29 μM, 10.65 μM, and 7.70 μM for THP-1, ZR-75-30, BT474, and H1975 cells, respectively[1].
Chemical Properties
Molecular Weight340.36
FormulaC16H12N4O3S
Cas No.941521-45-5
Smiles[O-][N+](=O)c1cccc(NC(=O)Nc2nc(cs2)-c2ccccc2)c1
Relative Density.1.481 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (235.05 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9381 mL14.6903 mL29.3807 mL146.9033 mL
5 mM0.5876 mL2.9381 mL5.8761 mL29.3807 mL
10 mM0.2938 mL1.4690 mL2.9381 mL14.6903 mL
20 mM0.1469 mL0.7345 mL1.4690 mL7.3452 mL
50 mM0.0588 mL0.2938 mL0.5876 mL2.9381 mL
100 mM0.0294 mL0.1469 mL0.2938 mL1.4690 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

ZR-75–30THP-10lung cancerleukemiaInhibitorinhibitH1975EpigeneticReaderDomainEpigenetic Reader DomaincancerBT474bromodomain-containingbreast cancerBAZ1A-IN-1BAZ-1A-IN-1BAZ1AIN1BAZ1A IN 1BAZ1A
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