JMS-17-2 hydrochloride

Name: JMS-17-2 hydrochloride
Brand: TargetMol
SKU: T39879
Rating: 4.5 (1 reviews)

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Catalog No. T39879Cas No. 2341841-07-2

JMS-17-2 hydrochloride, a highly potent and selective CX3CR1 antagonist with an IC 50 value of 0.32 nM, effectively impedes the metastatic seeding and colonization process of breast cancer cells.

JMS-17-2 hydrochloride

😃Good

Catalog No. T39879Cas No. 2341841-07-2

JMS-17-2 hydrochloride, a highly potent and selective CX3CR1 antagonist with an IC 50 value of 0.32 nM, effectively impedes the metastatic seeding and colonization process of breast cancer cells.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$957	35 days	35 days
50 mg	$3,920	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	JMS-17-2 hydrochloride, a highly potent and selective CX3CR1 antagonist with an IC 50 value of 0.32 nM, effectively impedes the metastatic seeding and colonization process of breast cancer cells.
Targets&IC50	CX3CR1:0.32 nM (IC50)
In vivo	JMS-17-2 (10 mg/kg; administered i.p.; twice a day for three weeks) significantly reduces tumor presence in the skeletal and visceral organs of SCID mice with MDA-231 xenografts[1], underscoring its effectiveness and demonstrating promise for further research into its anti-tumor capabilities.

Chemical Properties

Molecular Weight	456.41
Formula	C₂₅H₂₇Cl₂N₃O
Cas No.	2341841-07-2
Smiles	Cl.Clc1ccc(cc1)C1CCN(CCCn2c3ccccc3n3cccc3c2=O)CC1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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