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Cenerimod

Name: Cenerimod
Brand: TargetMol
SKU: T14924
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14924Cas No. 1262414-04-9

Alias ACT-334441

Cenerimod (ACT-334441) is an orally active, selective, and potent sphingosine 1-phosphate receptor (S1P1) agonist (EC50: 1 nM).Cenerimod inhibits multiple S1P isoforms and can be used to study murine experimental autoimmune encephalomyelitis (EAE) and murine scleroderma.

Cenerimod

🥰Excellent

Purity: 99.97%

Catalog No. T14924Alias ACT-334441Cas No. 1262414-04-9

Pack Size	Price	Availability
2 mg	$35	In Stock
5 mg	$56	In Stock
10 mg	$95	In Stock
25 mg	$155	In Stock
50 mg	$228	In Stock
1 mL x 10 mM (in DMSO)	$62	In Stock

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Batch Information

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Purity:99.97%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Cenerimod (ACT-334441) is an orally active, selective, and potent sphingosine 1-phosphate receptor (S1P1) agonist (EC50: 1 nM).Cenerimod inhibits multiple S1P isoforms and can be used to study murine experimental autoimmune encephalomyelitis (EAE) and murine scleroderma.
Targets&IC50	S1P5 receptor:36 nM (EC50), S1P1 receptor:1 nM (EC50), S1P5 receptor:228 nM (EC50), S1P4 receptor:2134 nM (EC50)
In vitro	Cultured fibroblasts were pretreated with a vehicle or Cenerimod (5 μmol/L), followed by incubation with TGF-β2 (10 ng/mL) for 24 hours. The results indicated that Cenerimod inhibited collagen production in fibroblasts[1].
In vivo	In male Wistar rats weighing 294-510 g, Cenerimod (0.1, 0.3, 1, 3, and 10 mg/kg; single oral dose) effectively and reversibly reduced blood lymphocyte counts[1].
Synonyms	ACT-334441

Chemical Properties

Molecular Weight	453.53
Formula	C₂₅H₃₁N₃O₅
Cas No.	1262414-04-9
Smiles	CCc1cc(cc(C)c1OC[C@@H](O)CO)-c1noc(n1)-c1cc(OC)nc(c1)C1CCCC1
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (176.39 mM), Sonification is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.28 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2049 mL	11.0246 mL	22.0493 mL	110.2463 mL
5 mM	0.4410 mL	2.2049 mL	4.4099 mL	22.0493 mL
10 mM	0.2205 mL	1.1025 mL	2.2049 mL	11.0246 mL
20 mM	0.1102 mL	0.5512 mL	1.1025 mL	5.5123 mL
50 mM	0.0441 mL	0.2205 mL	0.4410 mL	2.2049 mL
100 mM	0.0220 mL	0.1102 mL	0.2205 mL	1.1025 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc