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Vecuronium bromide

Name: Vecuronium bromide
Brand: TargetMol
SKU: T1594
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1594Cas No. 50700-72-6

Alias ORG NC 45

Vecuronium bromide (ORG NC 45) is a synthetic, intermediate-acting, mono-quaternary steroid that functions as a non-depolarizing neuromuscular blocking agent with muscle relaxant properties.

Vecuronium bromide

🥰Excellent

Purity: 99.92%

Catalog No. T1594Alias ORG NC 45Cas No. 50700-72-6

Vecuronium bromide (ORG NC 45) is a synthetic, intermediate-acting, mono-quaternary steroid that functions as a non-depolarizing neuromuscular blocking agent with muscle relaxant properties.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$45	In Stock	In Stock
50 mg	$68	In Stock	In Stock
100 mg	$98	In Stock	In Stock
500 mg	$217	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.92%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Vecuronium bromide (ORG NC 45) is a synthetic, intermediate-acting, mono-quaternary steroid that functions as a non-depolarizing neuromuscular blocking agent with muscle relaxant properties.
In vitro	Vecuronium inhibits both forms of the muscle-type acetylcholine receptor (IC50: 1-2 nM). Vecuronium combined with methylprednisolone shows additive effects on both receptor forms.[1] Vecuronium interferes with nicotinic processes in the carotid body and inhibits the chemoreceptor neural response to hypoxia. Vecuronium significantly attenuates the increase in CSNA (DeltaCSNA) in response to hypoxia in the carotid body.[2]
In vivo	Vecuronium has a higher biliary clearance than pancuronium in the rats.[3]
Synonyms	ORG NC 45

Chemical Properties

Molecular Weight	637.73
Formula	C₃₄H₅₇BrN₂O₄
Cas No.	50700-72-6
Smiles	[Br-].CC(=O)OC1C(CC2C3CCC4CC(OC(C)=O)C(CC4(C)C3CCC12C)N1CCCCC1)[N+]1(C)CCCCC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 4 mg/mL (6.27 mM), Sonication is recommended.

Ethanol: 93 mg/mL (145.83 mM), Sonication is recommended.

DMSO: 100 mg/mL (156.81 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.17 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5681 mL	7.8403 mL	15.6806 mL	78.4031 mL
5 mM	0.3136 mL	1.5681 mL	3.1361 mL	15.6806 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
10 mM	0.1568 mL	0.7840 mL	1.5681 mL	7.8403 mL
20 mM	0.0784 mL	0.3920 mL	0.7840 mL	3.9202 mL
50 mM	0.0314 mL	0.1568 mL	0.3136 mL	1.5681 mL
100 mM	0.0157 mL	0.0784 mL	0.1568 mL	0.7840 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc