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CAT-2200
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Catalog No. T9901A-1447
CAT-2200 is a human monoclonal antibody (IgG1/lambda) targeting Interleukin-17A (IL-17A/CTLA-8). IL-17A is a critical pro-inflammatory cytokine produced by Th17 cells, playing a central role in the pathology of autoimmune diseases such as psoriasis, rheumatoid arthritis, and multiple sclerosis. CAT-2200 specifically binds to the IL-17A homodimer, blocking its interaction with cell surface receptors (IL-17RA/IL-17RC), thereby effectively neutralizing the biological activity of IL-17A. Studies demonstrate that CAT-2200 significantly inhibits the IL-17A-induced release of downstream inflammatory mediators (e.g., IL-6, IL-8, and GRO-alpha). This antibody is frequently used as a tool antibody or positive control for researching the IL-17A signaling pathway and its role in inflammatory responses.
CAT-2200
CAT-2200
Copy Product Info🥰Excellent
Catalog No. T9901A-1447
CAT-2200 is a human monoclonal antibody (IgG1/lambda) targeting Interleukin-17A (IL-17A/CTLA-8). IL-17A is a critical pro-inflammatory cytokine produced by Th17 cells, playing a central role in the pathology of autoimmune diseases such as psoriasis, rheumatoid arthritis, and multiple sclerosis. CAT-2200 specifically binds to the IL-17A homodimer, blocking its interaction with cell surface receptors (IL-17RA/IL-17RC), thereby effectively neutralizing the biological activity of IL-17A. Studies demonstrate that CAT-2200 significantly inhibits the IL-17A-induced release of downstream inflammatory mediators (e.g., IL-6, IL-8, and GRO-alpha). This antibody is frequently used as a tool antibody or positive control for researching the IL-17A signaling pathway and its role in inflammatory responses.
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| Description | CAT-2200 is a human monoclonal antibody (IgG1/lambda) targeting Interleukin-17A (IL-17A/CTLA-8). IL-17A is a critical pro-inflammatory cytokine produced by Th17 cells, playing a central role in the pathology of autoimmune diseases such as psoriasis, rheumatoid arthritis, and multiple sclerosis. CAT-2200 specifically binds to the IL-17A homodimer, blocking its interaction with cell surface receptors (IL-17RA/IL-17RC), thereby effectively neutralizing the biological activity of IL-17A. Studies demonstrate that CAT-2200 significantly inhibits the IL-17A-induced release of downstream inflammatory mediators (e.g., IL-6, IL-8, and GRO-alpha). This antibody is frequently used as a tool antibody or positive control for researching the IL-17A signaling pathway and its role in inflammatory responses. |
| Targets&IC50 | IL-8:~8 nM, IL-6:~8 nM |
| In vitro | CAT-2200 binds human IL-17A with picomolar affinity. In primary chondrocytes or fibroblasts, it dose-dependently inhibits IL-6 and IL-8 secretion (IC50 ≈ 8 nM). Structural analysis shows it binds the IL-17A dimer, sterically hindering receptor access [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | CTLA-8/IL-17a |
| Isotype | IgG1 |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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