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Nampt activator-1

Name: Nampt activator-1
Brand: TargetMol
SKU: T67925
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67925Cas No. 701929-65-9

NAMPT Activator-1 (compound 1) is an effective and specific activator of niacinamide phosphotransferase (Compound 1) with a wide range of EC50 (3.3-3.7 μM). NAMPT activator-1 effectively protects cultured cells from FK866-mediated toxicity and is a potential neuroprotective compound.

Nampt activator-1

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Purity: 99.98%

Catalog No. T67925Cas No. 701929-65-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$222	In Stock	In Stock
50 mg	$347	-	In Stock
100 mg	$563	-	In Stock
500 mg	$1,180	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Nampt activator-1 AI Summary

Nampt activator-1 shows various bioactivities as follows: - It inhibits the MLL CXXC domain-DNA interaction with a potency of 15848.9 nM. - Demonstrates inhibitory activity on the Influenza NS1 Protein with a potency of 281.8 nM. - Exhibits inhibitory and activator activity on Human alpha-Glucosidase for the potential treatment of Pompe Disease, both with a potency of 56234.1 nM. - Inhibits BAZ2B with a potency of 707.9 nM. - Shows delayed death inhibitory effect on the malarial parasite plastid with a potency of 11689.1 nM. - Inhibits Polymerase Iota with a potency of 100000.0 nM and TGF-b with a potency of 3981.1 nM. - Acts as an inverse agonist on the GLP-1 Receptor with a potency of 28183.8 nM. - Works as an agonist for the gsp mutation responsible for Fibrous Dysplasia/McCune-Albright Syndrome with a potency of 35481.3 nM. - Activates integrin-mediated alleviation for Muscular Dystrophy with a potency of 1122.0 nM. - Inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) with a potency of 3662.6 nM. - Inhibits MBNL1-poly(CUG) RNA binding with a potency of 63095.7 nM. - Activates human NAMPT, leading to an increase in NMN production with an EC50 of approximately 3250.0 nM and a maximum increase of 75-98% relative to control or a reference compound at specific concentrations..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	NAMPT Activator-1 (compound 1) is an effective and specific activator of niacinamide phosphotransferase (Compound 1) with a wide range of EC50 (3.3-3.7 μM). NAMPT activator-1 effectively protects cultured cells from FK866-mediated toxicity and is a potential neuroprotective compound.
Targets&IC50	NAMPT:3.3-3.7 μM (EC50)

Chemical Properties

Molecular Weight	299.32
Formula	C₁₆H₁₇N₃O₃
Cas No.	701929-65-9
Smiles	CCOC(=O)c1ccc(NC(=O)NCc2ccncc2)cc1
Relative Density.	1.248 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (751.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (11.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3409 mL	16.7045 mL	33.4091 mL	167.0453 mL
5 mM	0.6682 mL	3.3409 mL	6.6818 mL	33.4091 mL
10 mM	0.3341 mL	1.6705 mL	3.3409 mL	16.7045 mL
20 mM	0.1670 mL	0.8352 mL	1.6705 mL	8.3523 mL
50 mM	0.0668 mL	0.3341 mL	0.6682 mL	3.3409 mL
100 mM	0.0334 mL	0.1670 mL	0.3341 mL	1.6705 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc