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M-CSF/CSF1 Protein, Human, Recombinant (E. coli)

Catalog No. TMPS-00155

M-CSF/CSF1 Protein, Human, Recombinant (E. coli) is expressed in E. coli. The accession number is P09603-3.

M-CSF/CSF1 Protein, Human, Recombinant (E. coli)

M-CSF/CSF1 Protein, Human, Recombinant (E. coli)

Catalog No. TMPS-00155
M-CSF/CSF1 Protein, Human, Recombinant (E. coli) is expressed in E. coli. The accession number is P09603-3.
Pack SizePriceAvailabilityQuantity
10 μg $1707-10 days
100 μg $9877-10 days
1 mg $4,7507-10 days
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Product Information

Biological Activity
ED 50 of 1.0-3.0 ng/ml, measured by cell proliferation assay of M-NFS-60, corresponding to a specific activity of 3.3 × 10 5 -1.0 × 10 6 units/mg.
Description
M-CSF/CSF1 Protein, Human, Recombinant (E. coli) is expressed in E. coli. The accession number is P09603-3.
Species
Human
Expression System
E. coli
TagTag Free
Accession NumberP09603-3
Synonyms
MGI-IM,MGC31930,MCSF,Macrophage Colony Stimulating Factor,Lanimostim,CSF-1,CSF1,colony stimulating factor 1
Construction
Glu33-Ser190
Protein Purity
> 95% as determined by SDS-PAGE
Molecular Weight~28 kDa (Non-reducing conditions)
Endotoxin< 1 EU/μg of protein as determined by the LAL method.
FormulationLyophilized after extensive dialysis against 50 mM Tris-HCl, pH 8.0.
Reconstitution
It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS or Tris-HCl, pH 8.0 up to 100 μg/ml.
Stability & Storage
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
ShippingIn general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background
Macrophage-Colony Stimulating Factor (M-CSF), also known as Colony Stimulating Factor-1 (CSF-1), is a hematopoietic growth factor. It can stimulate the survival, proliferation and differentiation of mononuclear phagocytes, in addition to the spreading and motility of macrophages. In mammals, it exits three isoforms, which invariably share an N-terminal 32-aa signal peptide, a 149-residue growth factor domain, a 21-residue transmembrane region and a 37-aa cytoplasmictail. M-CSF is mainly produced by monocytes, macrophages, fibroblasts, and endothelial cells. M-CSF interaction with its receptor, c-fms, has been implicated in the growth, invasion, and metastasis of of several diseases, including breast and endometrial cancers. The biological activity of human M-CSF is maintained within the 149-aa growth factor domain, and it is only active in the disulfide-linked dimeric form, which is bonded at Cys63.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Tech Support

Please read the User Guide of Recombinant Proteins for more specific information.