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alpha-Mangostin

Name: alpha-Mangostin
Brand: TargetMol
SKU: T1717
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1717Cas No. 6147-11-1

Alias α-Mangostin, Mangostin

alpha-Mangostin (Mangostin) is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.

alpha-Mangostin

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Purity: 99.84%

Catalog No. T1717Alias α-Mangostin, MangostinCas No. 6147-11-1

alpha-Mangostin (Mangostin) is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$41	In Stock	In Stock
25 mg	$91	In Stock	In Stock
50 mg	$166	In Stock	In Stock
100 mg	$316	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.84%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	alpha-Mangostin (Mangostin) is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
Targets&IC50	IDH1 (mutant, R132H):2.85 μM(ki)
In vitro	Alpha-mangostin exhibits a selective inhibitory effect on IDH1-R132H, but not on IDH1. Alpha-mangostin competitively inhibits the binding of alpha-mangostin (α-KG) to IDH1-R132H. The structure–relationship study reveals that alpha-mangostin exhibits the strongest core inhibitor structure. Alpha-mangostin selectively promotes demethylation of 5-methylcytosine (5mC) and histone H3 trimethylated lysine residues in IDH1 (+/R132H) MCF10A cells[1]. Cell proliferation significantly decreases in a dose-dependent manner in the cells treated with alpha-mangostin. Alpha-mangostin also increases the levels of Bax (pro-apoptotic), cleaved caspase-3, cleaved caspase-9 and cleaved-poly(ADP-ribose) polymerase (PARP)[2]. Alpha-mangostin significantly inhibits light-induced degeneration of photoreceptors and 200 μM Water2-induced apoptosis of RPE cells. 200 μM Water2-induced generation of reactive oxygen species (ROS) and light-induced generation of malondialdehyde (MDA) are suppressed by alpha-mangostin[3].
In vivo	Alpha-mangostin mitigates the risk of liver fibrosis by diminishing p53 expression relative to TAA_DMSO treatment. Moreover, following α-mangostin administration, serum concentrations of liver enzymes AST and ALT are reduced in comparison to treatment with DMSO alone[4].
Cell Research	IDH1+/+ and IDH1
Synonyms	α-Mangostin, Mangostin

Chemical Properties

Molecular Weight	410.46
Formula	C₂₄H₂₆O₆
Cas No.	6147-11-1
Smiles	C(C=C(C)C)C1=C2C(OC=3C(C2=O)=C(O)C(CC=C(C)C)=C(O)C3)=CC(O)=C1OC
Relative Density.	1.265 g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 252.5 mg/mL (615.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (4.87 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4363 mL	12.1815 mL	24.3629 mL	121.8145 mL
5 mM	0.4873 mL	2.4363 mL	4.8726 mL	24.3629 mL
10 mM	0.2436 mL	1.2181 mL	2.4363 mL	12.1815 mL
20 mM	0.1218 mL	0.6091 mL	1.2181 mL	6.0907 mL
50 mM	0.0487 mL	0.2436 mL	0.4873 mL	2.4363 mL
100 mM	0.0244 mL	0.1218 mL	0.2436 mL	1.2181 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc